科研成果汇总
汇聚全院卓越智慧，展示在顶级国际期刊发表的里程碑式研究成果。
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Ruonan Tian; Yawei Gao; Shaorong Gao; Hongqing Liang; Xijia Chen; Weikang Meng; Jiabao Bu; Jiaxu Wang; Yuli Qian; Danya Wu; Zhengyi Li; Fei Huang; Yun-Shen Chan; Jun Ma; You Wu; Yangquan Xiang; Zhipeng Ai; Dan Zhang; Wanlu Liu; Li Shen
Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets
Ke Tang, Ya Han, Dongqing Sun, Xin Dong, Tong Han, Hailin Wei, Wenwen Shao, Junjie Hu, Zhaoyang Liu, Lele Zhang, Taiwen Li, Peng Zhang, Qiu Wu, Chenfei Wang
Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation
Yunpeng Bi, Lishan Yu, Qidong Deng, Linghao Kong, Fuhu Guo, Yuchen Zhang, Ruixiang Wang, Peng R. Chen, Jun Liu, Xinyuan Fan
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Qing Dai, Tanner Baldwin, Ruitu Lyu, Bryan Daniels, Chang Ye, Chen Cao, Chenyou Zhu, Diwen Fan, Liane Lin, Yushuai Liu, Yiding Wang, Chuan He
Oligoclonal tumor-specific CD8 T-cell revival and IRE1α/XBP1-GDF15-mediated immunosuppressive niches determine neoadjuvant chemoimmunotherapy efficacy in cervical cancer
Guangxu Cao, Yuhan Wang, Huimin Zeng, Yong Zhi, Yi Guo, Mengting Xu, Yetian Ruan, Ying Wang, Yuhang Xiao, Jianqiao Lu, Ka Yu Tse, Jinli Gao, Qingfeng Zhang, Chenfei Wang, Zhiqiang Han, Fang Li
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
Xuehao Zhu, Zhanhe Chang, Weide Xiao, Xinbao Zhang, Mingli Ma, Jiang Wu, Jindian Hu, Yan Bi, Xiaochen Kou, Yanhong Zhao, Yifan Sheng, Baoxing Dong, Jiaxing Sun, Che Chen, You Wu, Xuelian Liu, Wenqing Ding, Kaiyuan Jia, Yingfan Yao, Lihua Sun, Xianbin Yu, Hong Wang, Jun Liu, Yixuan Wang, Shaorong Gao, Yawei Gao
Benchmarking single-cell multi-modal data integrations
Shaliu Fu, Shuguang Wang, Duanmiao Si, Gaoyang Li, Yawei Gao, Qi Liu
Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation
Yutao Zhao; Hui-Lung Sun; Wenlong Li; Chang Ye; Xiaoyang Dou; Yong Peng; Tong Wu; Pingluan Wang; Cheng-Wei Ju; Shun Liu; Yuhao Zhong; Qing Dai; Kinga Pajdzik; Chuan He
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Qing Dai; Tanner Baldwin; Ruitu Lyu; Bryan Daniels; Chang Ye; Chen Cao; Chenyou Zhu; Diwen Fan; Liane Lin; Yushuai Liu; Yiding Wang; Chuan He
Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution
Luzhang Ji, Qihang Zou, Ke Tang, Chenfei Wang
Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution
Cheng-Wei Ju, Han Li, Bochen Jiang, Xuanhao Zhu, Liang Cui, Zhanghui Han, Junxi Zou, Yunzheng Liu, Shenghai Shen, Hardik Shah, Chang Ye, Yuhao Zhong, Ruiqi Ge, Peng Xia, Yiyi Ji, Shun Liu, Fan Yang, Bei Liu, Yuzhi Xu, Jiangbo Wei, Li-Sheng Zhang, Chuan He
Discovery of circulating cell-free DNA 5hmC biomarkers for peritoneal metastasis in colorectal and appendiceal cancer
Yuri F. M. Malina; Lu Gao; Ankit Dhiman; Diana C. West-Szymanski; Yaniv Berger; Xiao-Long Cui; Zhou Zhang; Marco Rivas; Urszula Dougherty; Chang Ye; Akushika Kwesi; Zifeng Deng; Biren Reddy; Hunter D.D. Witmer; Phillip J. Hsu; Chuan He; Wei Zhang; Marc Bissonnette; Kiran Turaga
Multigenerational proteolytic inactivation of restriction upon subtle genomic hypomethylation in Pseudomonas aeruginosa
Esther Shmidov; Alexis Villani; Senén D. Mendoza; Ellay Avihu; Ilana Lebenthal-Loinger; Sarit Karako-Lampert; Sivan Shoshani; Chang Ye; Yiding Wang; Hao Yan; Weixin Tang; Joseph Bondy-Denomy; Ehud Banin
Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity
Ya Han, Lele Zhang, Dongqing Sun, Guangxu Cao, Yuting Wang, Jiali Yue, Junjie Hu, Zhonghua Dong, Fang Li, Taiwen Li, Peng Zhang, Qiu Wu, Chenfei Wang
Molecular mechanisms and crop improvement potential of RNA N6-methyladenosine in plants
Diyi Fu; Huiyuan Wang; Bochen Jiang
Structural insights into human Pol III transcription initiation in action
Qianmin Wang, Yulei Ren, Qianwei Jin, Xizi Chen, Yanhui Xu
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples
Cheng-Wei Ju, Ruitu Lyu, Han Li, Jiangbo Wei, Alberto J. Parra Vitela, Urszula Dougherty, Akushika Kwesi, Alexander Luna, Xuanhao Zhu, Shenghai Shen, Yunzheng Liu, Liangliang Wang, Xiaolong Cui, Yuzhi Xu, Bochen Jiang, Yiyi Ji, Peng Xia, Diana C. West-Szymanski, Chenxi Sun, Yuhao Zhong, Chang Ye, Angelica Moran, Christopher Lehmann, Eric Pamer, Wei Zhang, Marc Bissonnette, Li-Sheng Zhang, Chuan He
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA
Pingluan Wang; Chang Ye; Michelle Zhao; Bochen Jiang; Chuan He
Liquid–liquid phase separation regulates gene expression in plants
Diyi Fu; Bochen Jiang
Advanced eTAM-seq enables high-fidelity, low-input N6-methyladenosine profiling in human cells and embryonic mouse tissues
He, E.M.; Wu, Y.; Ye, C.; Zeng, T.-B.; He, C.; Tang, W.
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions
Lei Yang, Mingli Ma, Yawei Gao, Jun Liu
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions
Lei Yang; Mingli Ma; Yawei Gao; Jun Liu
FMR1 KH0-KH1 Domains Coordinate m6A Binding and Phase Separation in Fragile X Syndrome
Xian Zhou; Chen-Jun Guo; Rui Wang; Yi-Lan Li; Tianyi Zhang; Zhuangyi Qiu; Shaorong Gao; Ji-Long Liu; Yawei Gao
Monocyte–macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti‐melanoma differentiation‐associated gene 5‐positive dermatomyositis‐related interstitial lung disease
Jia Shi, Xiaoya Pei, Jinmin Peng, Chanyuan Wu, Yulin Lv, Xiaoman Wang, Yangzhong Zhou, Xueting Yuan, Xingbei Dong, Shuang Zhou, Dong Xu, Jiuliang Zhao, Jun Liu, Jiao Huang, Bin Du, Chen Yao, Xiaofeng Zeng, Mengtao Li, Houzao Chen, Qian Wang
Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Haoxuan Li; Guanqun Wang; Chang Ye; Zhongyu Zou; Bochen Jiang; Fan Yang; Kayla He; Chengwei Ju; Lisheng Zhang; Boyang Gao; Shun Liu; Yanming Chen; Jianhua Zhang; Chuan He
Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Haoxuan Li; Guanqun Wang; Chang Ye; Zhongyu Zou; Bochen Jiang; Fan Yang; Kayla He; Chengwei Ju; Lisheng Zhang; Boyang Gao; Shun Liu; Yanming Chen; Jianhua Zhang; Chuan He
BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing
Moping Xu, Xiaoyang Liu, Miao Wang, Tingting Luo, Yawei Gao, Jun Liu, Jiejun Shi
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Haoxuan Li; Guanqun Wang; Chang Ye; Zhongyu Zou; Bochen Jiang; Fan Yang; Kayla He; Chengwei Ju; Lisheng Zhang; Boyang Gao; Shun Liu; Yanming Chen; Jianhua Zhang; Chuan He
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Haoxuan Li; Guanqun Wang; Chang Ye; Zhongyu Zou; Bochen Jiang; Fan Yang; Kayla He; Chengwei Ju; Lisheng Zhang; Boyang Gao; Shun Liu; Yanming Chen; Jianhua Zhang; Chuan He
ScRAPdb: an integrated pan-omics database for the Saccharomyces cerevisiae reference assembly panel
Zepu Miao; Yifan Ren; Andrea Tarabini; Ludong Yang; Huihui Li; Chang Ye; Gianni Liti; Gilles Fischer; Jing Li; Jia-Xing Yue
METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m6A methylation in humans and mice
Mengya Zhang, Xueguang Zhang, Chen Tan, Ting Jiang, Zheng Cao, Yufei Chen, Feng Qiao, Gelin Huang, Chaoye Ma, Huixia Li, Mei Ye, Lei Wang, Liandong Zuo, Jun Yu, Xiaofeng Li, Yunfang Zhang, Yue-Qiu Tan, Shuibin Lin, Wenming Xu, Hao Chen
Hypoxia exposure impairs male fertility via inhibiting Septin2-mediated spermatogonial proliferation
Zhibin Li, Shuying Li, Yufeng Xiao, Junfeng Guo, Jianchun Zhou, Yang Chen, Juan Yang, Chunli Gong, Bing He, Yuyun Wu, Nannan Gao, Huan Yang, Limin Gao, Hua Hu, Yunfang Zhang, Shiming Yang
LAMP‐MS for Locus‐Specific Visual Quantification of DNA 5 mC and RNA m6A Using Ultra‐Low Input
Runyu Xie, Xiaotong Yang, Weizhi He, Zhongguang Luo, Wenshuai Li, Chu Xu, Xiaolong Cui, Wei Zhang, Ning Wei, Xiaolan Wang, Yixiang Shi, Chuan He, Jie Liu, Lulu Hu
Profiling RNA subcellular localization in situ by TATA-seq
Junjie Li, Chu Xu, Xiao Jiang, Xinxin Huang, Dan Ye, LuLu Hu
Deciphering the RNA landscapes on mammalian cell surfaces
Xiao Jiang, Chu Xu, Enzhuo Yang, Danhua Xu, Yong Peng, Xue Han, Jingwen Si, Qixin Shao, Zhuo Liu, Qiuxiao Chen, Weizhi He, Shuang He, Yanhui Xu, Chuan He, Xinxin Huang, Lulu Hu
Uli-epic: profiling RNA modifications from ultra-low input samples
Weizhi He, Chu Xu, Wen Chen, Xiao Jiang, Yuhang Wang, Yong Peng, Shujuan Chang, Wei Zhu, Jiuhong Kang, Lulu Hu
NAT10 primes a post-transcriptional repertoire essential for the maintenance of spermatogonial homeostasis
Xiaoli Zhu, Caoling Xu, Xue Jiang, Jiaqi Zou, Wenqing Li, Xuemei Xing, Xiaoxiao Gao, Jiao Lei, Fei Meng, Xin Wang, Yuzhang Zhu, Yu Cheng, Muhammad Azhar, Wenjie Han, Ge Lin, Yunfang Zhang, Ge Shan, Shen Zhang, Jianqiang Bao
Optimized identification and characterization of small RNAs with PANDORA-seq
Junchao Shi, Yunfang Zhang, Yun Li, Liwen Zhang, Xudong Zhang, Menghong Yan, Qi Chen, Ying Zhang
Single-cell omics: experimental workflow, data analyses and applications
Fengying Sun, Haoyan Li, Dongqing Sun, Shaliu Fu, Lei Gu, Xin Shao, Qinqin Wang, Xin Dong, Bin Duan, Feiyang Xing, Jun Wu, Minmin Xiao, Fangqing Zhao, Jing-Dong J. Han, Qi Liu, Xiaohui Fan, Chen Li, Chenfei Wang, Tieliu Shi
Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer
Yilv Yan, Dongqing Sun, Junjie Hu, Yue Chen, Liangdong Sun, Huansha Yu, Yicheng Xiong, Zhida Huang, Haoran Xia, Xinsheng Zhu, Dongliang Bian, Fenghuan Sun, Likun Hou, Chunyan Wu, Orion R. Fan, Haiyang Hu, An Zeng, Lele Zhang, Yi Eve Sun, Chenfei Wang, Peng Zhang
FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of gene expression in cancer
Xinning Zhang, Yifan Zhang, Xinyu Liu, Chang Liu, Ying Liu, Yuan He, Yuhang Qiu, Lida Sun, Jing Hu, Yawei Gao, Wensheng Wei, Jun Liu
BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing
Moping Xu; Xiaoyang Liu; Miao Wang; Tingting Luo; Yawei Gao; Jun Liu; Jiejun Shi
FMR1 KH0-KH1 domains coordinate m6A binding and phase separation in Fragile X syndrome
Xian Zhou; Chen-Jun Guo; Rui Wang; Yi-Lan Li; Tianyi Zhang; Zhuangyi Qiu; Shaorong Gao; Ji-Long Liu; Yawei Gao
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA
Pingluan Wang; Chang Ye; Michelle Zhao; Bochen Jiang; Chuan He
Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution
Cheng-Wei Ju; Han Li; Bochen Jiang; Xuanhao Zhu; Liang Cui; Zhanghui Han; Junxi Zou; Yunzheng Liu; Shenghai Shen; Hardik Shah; Chang Ye; Yuhao Zhong; Ruiqi Ge; Peng Xia; Yiyi Ji; Shun Liu; Fan Yang; Bei Liu; Yuzhi Xu; Jiangbo Wei; Li-Sheng Zhang; Chuan He
Nuclear 2′-O-methylation regulates RNA splicing through its binding protein FUBP1
Lisheng Zhang; Boyang Gao; Chuan He; Bochen Jiang; Zhongyu Zou; Bei Liu; Weijin Liu; Li Chen
Single-cell dissection of multifocal bladder cancer reveals malignant and immune cells variation between primary and recurrent tumor lesions
Shenghua Liu, Chenchen Feng, Linyi Tan, Dengwei Zhang, Yong-xin Li, Ya Han, Chenfei Wang
Light‐induced cryptochrome 2 liquid–liquid phase separation and mRNA methylation
Bochen Jiang
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Zhongyu Zou, Xiaoyang Dou, Ying Li, Zijie Zhang, Juan Wang, Boyang Gao, Yu Xiao, Yiding Wang, Lijie Zhao, Chenxi Sun, Qinzhe Liu, Xianbin Yu, Hao Wang, Juyeong Hong, Qing Dai, Feng-Chun Yang, Mingjiang Xu, Chuan He
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency
Jinjun Wu, Yu Xiao, Yunzheng Liu, Li Wen, Chuanyang Jin, Shun Liu, Sneha Paul, Chuan He, Oded Regev, Jingyi Fei
Differential phosphorylation of Ca2+-permeable channel CYCLIC NUCLEOTIDE–GATED CHANNEL20 modulates calcium-mediated freezing tolerance in Arabidopsis
Yue Peng; Yuhang Ming; Bochen Jiang; Xiuyue Zhang; Diyi Fu; Qihong Lin; Xiaoyan Zhang; Yi Wang; Yiting Shi; Zhizhong Gong; Yanglin Ding; Shuhua Yang
m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells
Zihong Kang, Ruimeng Li, Chang Liu, Xiaozhe Dong, Yuxuan Hu, Lei Xu, Xinyu Liu, Yunfan Xiang, Liming Gao, Wenzhe Si, Lei Wang, Qing Li, Liang Zhang, Huan Wang, Xuerui Yang, Jun Liu
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Qing Dai, Chang Ye, Iryna Irkliyenko, Yiding Wang, Hui-Lung Sun, Yun Gao, Yushuai Liu, Alana Beadell, José Perea, Ajay Goel, Chuan He
IGF2BP3 promotes mRNA degradation through internal m7G modification
Chang Liu, Xiaoyang Dou, Yutao Zhao, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan He
IGF2BP3 promotes mRNA degradation through internal m7G modification
Chang Liu, Xiaoyang Dou, Yutao Zhao, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan He
Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation
Yutao Zhao; Xinyuan Ma; Chang Ye; Wenlong Li; Kinga Pajdzik; Qing Dai; Hui-Lung Sun; Chuan He
PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
Matthew O. Ross; Yuan Xie; Ryan C. Owyang; Chang Ye; Olivia N. P. Zbihley; Ruitu Lyu; Tong Wu; Pingluan Wang; Olga Karginova; Olufunmilayo I. Olopade; Minglei Zhao; Chuan He
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq
Ruitu Lyu; Yun Gao; Tong Wu; Chang Ye; Pingluan Wang; Chuan He
Single-cell and spatial multiomic inference of gene regulatory networks using SCRIPro
Zhanhe Chang, Yunfan Xu, Xin Dong, Yawei Gao, Chenfei Wang
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis
Wang, G.; Li, H.; Ye, C.; He, K.; Liu, S.; Jiang, B.; Ge, R.; Gao, B.; Wei, J.; Zhao, Y.; Li, A.; Zhang, D.; Zhang, J.; He, C.
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis
Guanqun Wang; Haoxuan Li; Chang Ye; Kayla He; Shun Liu; Bochen Jiang; Ruiqi Ge; Boyang Gao; Jiangbo Wei; Yutao Zhao; Aixuan Li; Di Zhang; Jianhua Zhang; Chuan He
Pivotal role for long noncoding RNAs in zygotic genome activation in mice
Kang Chen, Wenju Liu, Jiang Zhu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang, Shaorong Gao, Lan Kang
Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation
Pomaville, M.; Chennakesavalu, M.; Wang, P.; Jiang, Z.; Sun, H.-L.; Ren, P.; Borchert, R.; Gupta, V.; Ye, C.; Ge, R.; Zhu, Z.; Brodnik, M.; Zhong, Y.; Moore, K.; Salwen, H.; George, R.E.; Krajewska, M.; Chlenski, A.; Applebaum, M.A.; He, C.; Cohn, S.L.
Chemical manipulation of m1A mediates its detection in human tRNA
Kinga Pajdzik; Ruitu Lyu; Xiaoyang Dou; Chang Ye; Li-Sheng Zhang; Qing Dai; Chuan He
The dual‐action mechanism of Arabidopsis cryptochromes
Gao‐Ping Qu; Bochen Jiang; Chentao Lin
Exploring transient global transcriptional changes induced by ascorbic acid revealed via atKAS-seq profiling
Xiangyue Liu, Weizhi He, Lulu Hu
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq
Ruitu Lyu; Yun Gao; Tong Wu; Chang Ye; Pingluan Wang; Chuan He
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
Yu Xiao, Yan-Ming Chen, Zhongyu Zou, Chang Ye, Xiaoyang Dou, Jinjun Wu, Chang Liu, Shun Liu, Hao Yan, Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu, Jingyi Fei, Weixin Tang, Chuan He
Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome
Xinran Feng, Xiaolong Cui, Li-Sheng Zhang, Chang Ye, Pingluan Wang, Yuhao Zhong, Tong Wu, Zhong Zheng, Chuan He
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
Yu Xiao, Yan-Ming Chen, Zhongyu Zou, Chang Ye, Xiaoyang Dou, Jinjun Wu, Chang Liu, Shun Liu, Hao Yan, Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu, Jingyi Fei, Weixin Tang, Chuan He
BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution
Zhang, L.-S.; Ye, C.; Ju, C.-W.; Gao, B.; Feng, X.; Sun, H.-L.; Wei, J.; Yang, F.; Dai, Q.; He, C.
METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control
Pan Zhao, Lin Xia, Dan Chen, Wei Xu, Huanping Guo, Yinying Xu, Bingbing Yan, Xiao Wu, Yuxia Li, Yunfang Zhang, Xi Zhang
Ascorbic Acid Reprograms Epigenome and Epitranscriptome by Reducing Fe(III) in the Catalytic Cycle of Dioxygenases
Weizhi He, Xiaotong Yin, Chu Xu, Xiangyue Liu, Yue Huang, Caiguang Yang, Yanhui Xu, Lulu Hu
tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators
Yun Li, Zongyu Yu, Wenlin Jiang, Xinyi Lyu, Ailian Guo, Xiaorui Sun, Yiting Yang, Yunfang Zhang
Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
Qian Liu, Jing Zhang, Chenchen Guo, Mengcheng Wang, Chenfei Wang, Yilv Yan, Liangdong Sun, Di Wang, Lele Zhang, Huansha Yu, Likun Hou, Chunyan Wu, Yuming Zhu, Gening Jiang, Hongwen Zhu, Yanting Zhou, Shanhua Fang, Tengfei Zhang, Liang Hu, Junqiang Li, Yansheng Liu, Hui Zhang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Daming Gao, Hongbin Ji, Hu Zhou, Peng Zhang
Small-Molecule Inhibition of Mettl3 Suppresses Neuroblastoma Tumor Growth and Promotes Differentiation
Pomaville, Monica; Jiang, Zhiwei; Wang, Pingluan; Chennakesavalu, Mohansrinivas; Ye, Chang; Ge, Ruiqi; Zou, Zhongyu; Brodnik, Mallory; Zhong, Yuhao; Moore, Kelley; others
Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development
Wenju Liu; Chuan Chen; Yawei Gao; Xinyu Cui; Yuhan Zhang; Liang Gu; Yuanlin He; Jing Li; Shaorong Gao; Rui Gao; Cizhong Jiang; Fuchou Tang
Interplay between the transcription preinitiation complex and the +1 nucleosome
Xizi Chen, Yanhui Xu
Structural insights into histone exchange by human SRCAP complex
Jiali Yu; Fengrui Sui; Feng Gu; Wanjun Li; Zishuo Yu; Qianmin Wang; Shuang He; Li Wang; Yanhui Xu
Structure of the human TIP60 complex
Ke Chen; Li Wang; Zishuo Yu; Jiali Yu; Yulei Ren; Qianmin Wang; Yanhui Xu
Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research
Gao, L.; Zhang, Z.; Cui, X.-L.; West-Szymanski, D.; Ye, C.; He, C.; Zhang, W.; Bissonnette, M.
Structural visualization of transcription initiation in action
Xizi Chen; Weida Liu; Qianmin Wang; Xinxin Wang; Yulei Ren; Xuechun Qu; Wanjun Li; Yanhui Xu
Author Correction: Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis (Nature Plants, (2023), 9, 12, (2042-2058), 10.1038/s41477-023-01580-0)
Jiang, B.; Zhong, Z.; Gu, L.; Zhang, X.; Wei, J.; Ye, C.; Lin, G.; Qu, G.; Xiang, X.; Wen, C.; Hummel, M.; Bailey-Serres, J.; Wang, Q.; He, C.; Wang, X.; Lin, C.
Author Correction: Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis
Bochen Jiang; Zhenhui Zhong; Lianfeng Gu; Xueyang Zhang; Jiangbo Wei; Chang Ye; Guifang Lin; Gaoping Qu; Xian Xiang; Chenjin Wen; Maureen Hummel; Julia Bailey-Serres; Qin Wang; Chuan He; Xu Wang; Chentao Lin
Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2
Yongfeng Tao, Jan G. Felber, Zhongyu Zou, Evert Njomen, Jarrett R. Remsberg, Daisuke Ogasawara, Chang Ye, Bruno Melillo, Stuart L. Schreiber, Chuan He, David Remillard, Benjamin F. Cravatt
Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis
Jiang, B.; Zhong, Z.; Gu, L.; Zhang, X.; Wei, J.; Ye, C.; Lin, G.; Qu, G.; Xiang, X.; Wen, C.; Gateas, M.; Bailey-Serres, J.; Wang, Q.; He, C.; Wang, X.; Lin, C.
Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis
Bochen Jiang; Zhenhui Zhong; Lianfeng Gu; Xueyang Zhang; Jiangbo Wei; Chang Ye; Guifang Lin; Gaoping Qu; Xian Xiang; Chenjin Wen; Maureen Hummel; Julia Bailey-Serres; Qin Wang; Chuan He; Xu Wang; Chentao Lin
Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling
Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu, Chuan He
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity
Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity
Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu
Single-cell assignment using multiple-adversarial domain adaptation network with large-scale references
Pengfei Ren, Xiaoying Shi, Zhiguang Yu, Xin Dong, Xuanxin Ding, Jin Wang, Liangdong Sun, Yilv Yan, Junjie Hu, Peng Zhang, Qianming Chen, Jing Zhang, Taiwen Li, Chenfei Wang
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Xiaoyang Dou, Yu Xiao, Chao Shen, Kitty Wang, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan He
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Xiaoyang Dou, Yu Xiao, Chao Shen, Kitty Wang, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan He
RBFOX2 recognizes N 6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Dou, X.; Xiao, Y.; Shen, C.; Wang, K.; Wu, T.; Liu, C.; Li, Y.; Yu, X.; Liu, J.; Dai, Q.; Pajdzik, K.; Ye, C.; Ge, R.; Gao, B.; Yu, J.; Sun, S.; Chen, M.; Chen, J.; He, C.
PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
Ross, M.O.; Xie, Y.; Owyang, R.C.; Ye, C.; Zbihley, O.N.P.; Lyu, R.; Wu, T.; Wang, P.; Karginova, O.; Olopade, O.I.; Zhao, M.; He, C.
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment
Guangxu Cao, Jiali Yue, Yetian Ruan, Ya Han, Yong Zhi, Jianqiao Lu, Min Liu, Xinxin Xu, Jin Wang, Quan Gu, Xuejun Wen, Jinli Gao, Qingfeng Zhang, Jiuhong Kang, Chenfei Wang, Fang Li
Small-Molecule Inhibition of Mettl3 Suppresses Neuroblastoma Tumor Growth and Promotes Differentiation
Pomaville, M.M.; Jiang, Z.; Wang, P.; Chennakesavalu, M.; Ye, C.; Ge, R.; Zhu, Z.; Brodnik, M.; Zhong, Y.; Moore, K.; Salwen, H.; Chlenski, A.; George, R.E.; Krajewska, M.; Applebaum, M.A.; He, C.; Cohn, S.L.
Co-condensation with photoexcited cryptochromes facilitates MAC3A to positively control hypocotyl growth in Arabidopsis
Bochen Jiang; Zhenhui Zhong; Jun Su; Tengfei Zhu; Timothy Yueh; Jielena Bragasin; Victoria Bu; Charles Zhou; Chentao Lin; Xu Wang
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He, Shuying Sun
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He, Shuying Sun
YTHDF2/m6A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs
Zhang, L.; Dou, X.; Zheng, Z.; Ye, C.; Lu, T.X.; Liang, H.L.; Wang, L.; Weichselbaum, R.R.; He, C.
Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications
Wang, Y.; Zhang, L.; Zhang, W.; Gao, B.; Ye, C.; Dai, Q.; Wang, K.; Luo, M.; Pan, T.; He, C.
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation
Chen, L.; Zhang, L.-S.; Ye, C.; Zhou, H.; Liu, B.; Gao, B.; Deng, Z.; Zhao, C.; He, C.; Dickinson, B.C.
SCREE: a comprehensive pipeline for single-cell multi-modal CRISPR screen data processing and analysis
Hailin Wei, Tong Han, Taiwen Li, Qiu Wu, Chenfei Wang
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing
Junjie Hu, Lele Zhang, Haoran Xia, Yilv Yan, Xinsheng Zhu, Fenghuan Sun, Liangdong Sun, Shuangyi Li, Dianke Li, Jin Wang, Ya Han, Jing Zhang, Dongliang Bian, Huansha Yu, Yan Chen, Pengyu Fan, Qiang Ma, Gening Jiang, Chenfei Wang, Peng Zhang
Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang, Qiu Wu, Ziyi Li, Jingxin Fu, Rongbin Zheng, Jiamin Zhang, Qin Tang, Peng Zhang, Chenfei Wang
Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution
Dai, Qing; Zhang, Li-Sheng; Sun, Hui-Lung; Pajdzik, Kinga; Yang, Lei; Ye, Chang; Ju, Cheng-Wei; Liu, Shun; Wang, Yuru; Zheng, Zhong; others
Hypoxia induces alterations in tRNA modifications involved in translational control
Huanping Guo, Lin Xia, Wei Wang, Wei Xu, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang, Yunfang Zhang
Resetting histone modifications during human prenatal germline development
Rui Gao; Shiyang Zeng; Dongxu Yang; Xiaocui Li; Wenqiang Liu; Yawei Gao; Dandan Bai; Linfeng Zhang; Chuan Chen; Yunzhe Kang; Beiying Wang; Wei Hong; Mingzhu Wang; Jiqing Yin; Hong Wang; Qiaolin Deng; Shaorong Gao; Yong Zhang; Jiayu Chen
m6A-SAC-seq for quantitative whole transcriptome m6A profiling
Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu, Chuan He
m6A-SAC-seq for quantitative whole transcriptome m6A profiling
Ge, R.; Ye, C.; Peng, Y.; Dai, Q.; Zhao, Y.; Liu, S.; Wang, P.; Hu, L.; He, C.
Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome
Feng, X.; Cui, X.; Zhang, L.-S.; Ye, C.; Wang, P.; Zhong, Y.; Zheng, Z.; He, C.
HUSCH: an integrated single-cell transcriptome atlas for human tissue gene expression visualization and analyses
Xiaoying Shi, Zhiguang Yu, Pengfei Ren, Xin Dong, Xuanxin Ding, Jiaming Song, Jing Zhang, Taiwen Li, Chenfei Wang
TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment
Ya Han, Yuting Wang, Xin Dong, Dongqing Sun, Zhaoyang Liu, Jiali Yue, Haiyun Wang, Taiwen Li, Chenfei Wang
scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei
Jiang Zhu, Kang Chen, Yu H. Sun, Wen Ye, Juntao Liu, Dandan Zhang, Nan Su, Li Wu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Shaorong Gao, Lan Kang
Human circulating small non-coding RNA signature as a non-invasive biomarker in clinical diagnosis of acute myeloid leukaemia
Lin Xia, Huanping Guo, Xiao Wu, Yinying Xu, Pan Zhao, Bingbing Yan, Yunjing Zeng, Yundi He, Dan Chen, Robert Peter Gale, Yunfang Zhang, Xi Zhang
Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome
Feng, Xinran; Cui, Xiaolong; Zhang, Li-Sheng; Ye, Chang; Wang, Pingluan; Zhong, Yuhao; Zheng, Zhong; He, Chuan
RBFOX2 recognizes N 6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Dou, Xiaoyang; Xiao, Yu; Shen, Chao; Wang, Kitty; Wu, Tong; Liu, Chang; Li, Yini; Yu, Xianbin; Liu, Jun; Dai, Qing; others
Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications
Wang, Yuru; Zhang, Lisheng; Zhang, Wen; Gao, Boyang; Ye, Chang; Dai, Qing; Wang, Ke; Luo, Minkui; Pan, Tao; He, Chuan
Structure of the SNAPc-bound RNA polymerase III preinitiation complex
Haifeng Hou; Qianwei Jin; Yulei Ren; Zhenguo Chen; Qianmin Wang; Yanhui Xu
Structural basis of INTAC-regulated transcription
Hai Zheng; Qianwei Jin; Xinxin Wang; Yilun Qi; Weida Liu; Yulei Ren; Dan Zhao; Fei Xavier Chen; Jingdong Cheng; Xizi Chen; Yanhui Xu
m7G-quant-seq: Quantitative Detection of RNA Internal N7-Methylguanosine
Zhang, L.-S.; Ju, C.-W.; Liu, C.; Wei, J.; Dai, Q.; Chen, L.; Ye, C.; He, C.
Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing
Yong Peng, Hanzhe Meng, Ruiqi Ge, Shun Liu, Mengjie Chen, Chuan He, Lulu Hu
Single-cell gene regulation network inference by large-scale data integration
Xin Dong, Ke Tang, Yunfan Xu, Hailin Wei, Tong Han, Chenfei Wang
Evaluation of cell-cell interaction methods by integrating single-cell RNA sequencing data with spatial information
Zhaoyang Liu, Dongqing Sun, Chenfei Wang
Structures of +1 nucleosome–bound PIC-Mediator complex
Xizi Chen; Xinxin Wang; Weida Liu; Yulei Ren; Xuechun Qu; Jiabei Li; Xiaotong Yin; Yanhui Xu
Quantitative and single nucleotide RNA m6A detection technology boosts clinical research based on tissue and cell free RNA modification
Lulu Hu
Alteration of RNA modification signature in human sperm correlates with sperm motility
Huanping Guo, Xipeng Shen, Hua Hu, Peng Zhou, Tong He, Lin Xia, Dongmei Tan, Xi Zhang, Yunfang Zhang
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Rui Su, Chamara Senevirathne, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang, Minkui Luo, Mengjie Chen, Jianjun Chen, Chuan He
Structural insights into assembly of transcription preinitiation complex
Xizi Chen; Yanhui Xu
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos
Ruimin Xu, Sen Li, Qiu Wu, Chong Li, Manxi Jiang, Lei Guo, Mo Chen, Lingyue Yang, Xin Dong, Hong Wang, Chenfei Wang, Xiaoyu Liu, Xianghong Ou, Shaorong Gao
Alterations of RNA Modification in Mouse Germ Cell-2 Spermatids Under Hypoxic Stress
Tong He, Huanping Guo, Lin Xia, Xipeng Shen, Yun Huang, Xiao Wu, Xuelin Jiang, Yinying Xu, Yi Tan, Yunfang Zhang, Dongmei Tan
FTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development
Jiangbo Wei, Xianbin Yu, Lei Yang, Xuelian Liu, Boyang Gao, Boxian Huang, Xiaoyang Dou, Jun Liu, Zhongyu Zou, Xiao-Long Cui, Li-Sheng Zhang, Xingsen Zhao, Qinzhe Liu, P. Cody He, Caraline Sepich-Poore, Nicole Zhong, Wenqiang Liu, Yanhe Li, Xiaochen Kou, Yanhong Zhao, You Wu, Xuejun Cheng, Chuan Chen, Yiming An, Xueyang Dong, Huanyu Wang, Qiang Shu, Ziyang Hao, Tao Duan, Yu-Ying He, Xuekun Li, Shaorong Gao, Yawei Gao, Chuan He
STRIDE: accurately decomposing and integrating spatial transcriptomics using single-cell RNA sequencing
Dongqing Sun, Zhaoyang Liu, Taiwen Li, Qiu Wu, Chenfei Wang
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Chenfei Wang, Chuan Chen, Xiaoyu Liu, Chong Li, Qiu Wu, Xiaolan Chen, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yawei Gao, Yong Zhang, Shaorong Gao
Paternal High-Fat Diet Altered Sperm 5'tsRNA-Gly-GCC Is Associated With Enhanced Gluconeogenesis in the Offspring
Bin Wang, Lin Xia, Dan Zhu, Hongtao Zeng, Bin Wei, Likui Lu, Weisheng Li, Yajun Shi, Jingliu Liu, Yunfang Zhang, Miao Sun
Metabolomic analyses reveal new stage-specific features of COVID-19
Jia, Hongling; Liu, Chaowu; Li, Dantong; Huang, Qingsheng; Liu, Dong; Zhang, Ying; Ye, Chang; Zhou, Di; Wang, Yang; Tan, Yanlian; Li, Kuibiao; Lin, Fangqin; Zhang, Haiqing; Lin, Jingchao; Xu, Yang; Liu, Jingwen; Zeng, Qing; Hong, Jian; Chen, Guobing; Zhang, Hao; Zheng, Lingling; Deng, Xilong; Ke, Changwen; Gao, Yunfei; Fan, Jun; Di, Biao; Liang, Huiying
Structure of nucleosome-bound human PBAF complex
Li Wang; Jiali Yu; Zishuo Yu; Qianmin Wang; Wanjun Li; Yulei Ren; Zhenguo Chen; Shuang He; Yanhui Xu
Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity
Zheng Wang, Chengyan Chai, Rui Wang, Yimei Feng, Lei Huang, Yiming Zhang, Xia Xiao, Shijie Yang, Yunfang Zhang, Xi Zhang
RNA demethylation increases the yield and biomass of rice and potato plants in field trials
Qiong Yu, Shun Liu, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song, Chuan He, Guifang Jia
Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development
Liu, K.; Deng, S.; Ye, C.; Yao, Z.; Wang, J.; Gong, H.; Liu, L.; He, X.
Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm
Tong He, Huanping Guo, Xipeng Shen, Xiao Wu, Lin Xia, Xuelin Jiang, Yinying Xu, Dan Chen, Yunfang Zhang, Dongmei Tan, Yi Tan
Publisher Correction: A photoregulatory mechanism of the circadian clock in Arabidopsis
Xu Wang; Bochen Jiang; Lianfeng Gu; Yadi Chen; Manuel Mora; Mulangma Zhu; Eliace Noory; Qin Wang; Chentao Lin
A photoregulatory mechanism of the circadian clock in Arabidopsis
Xu Wang; Bochen Jiang; Lianfeng Gu; Yadi Chen; Manuel Mora; Mulangma Zhu; Eliace Noory; Qin Wang; Chentao Lin
Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs
Yu H. Sun, Ruoqiao Huiyi Wang, Khai Du, Jiang Zhu, Jihong Zheng, Li Huitong Xie, Amanda A. Pereira, Chao Zhang, Emiliano P. Ricci, Xin Zhiguo Li
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth
Lihui Dong, Chuanyuan Chen, Yawei Zhang, Peijin Guo, Zhenghang Wang, Jian Li, Yi Liu, Jun Liu, Renbao Chang, Yilin Li, Guanghao Liang, Weiyi Lai, Mengxue Sun, Urszula Dougherty, Marc B. Bissonnette, Hailin Wang, Lin Shen, Meng Michelle Xu, Dali Han
Structures of the human Mediator and Mediator-bound preinitiation complex
Xizi Chen; Xiaotong Yin; Jiabei Li; Zihan Wu; Yilun Qi; Xinxin Wang; Weida Liu; Yanhui Xu
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
Chuan Chen, Wenqiang Liu, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu, Xiaoyang Dou, Rongrong Le, Yixin Huang, Chong Li, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, You Wu, Jiayu Chen, Hong Wang, Bin Shen, Yawei Gao, Shaorong Gao
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
Yi Liu, Guanghao Liang, Hongjiao Xu, Wenxin Dong, Ze Dong, Zhiwei Qiu, Zihao Zhang, Fangle Li, Yue Huang, Yilin Li, Jun Wu, Shenyi Yin, Yawei Zhang, Peijin Guo, Jun Liu, Jianzhong Jeff Xi, Peng Jiang, Dali Han, Cai-Guang Yang, Meng Michelle Xu
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.
Detailed Authors Missing in ORCID
Pooled CRISPR screening identifies m 6 A as a positive regulator of macrophage activation
Jiyu Tong, Xuefei Wang, Yongbo Liu, Xingxing Ren, Anmin Wang, Zonggui Chen, Jiameng Yao, Kaiqiong Mao, Tingting Liu, Fei-Long Meng, Wen Pan, Qiang Zou, Jun Liu, Yu Zhou, Qiang Xia, Richard A. Flavell, Shu Zhu, Hua-Bing Li
Decoding the epitranscriptional landscape from native RNA sequences
Piroon Jenjaroenpun, Thidathip Wongsurawat, Taylor D Wadley, Trudy M Wassenaar, Jun Liu, Qing Dai, Visanu Wanchai, Nisreen S Akel, Azemat Jamshidi-Parsian, Aime T Franco, Gunnar Boysen, Michael L Jennings, David W Ussery, Chuan He, Intawat Nookaew
LEAD‐m6A‐seq for Locus‐Specific Detection of N6‐Methyladenosine and Quantification of Differential Methylation
Yuru Wang, Zijie Zhang, Caraline Sepich‐Poore, Lisheng Zhang, Yu Xiao, Chuan He
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment
Dongqing Sun, Jin Wang, Ya Han, Xin Dong, Jun Ge, Rongbin Zheng, Xiaoying Shi, Binbin Wang, Ziyi Li, Pengfei Ren, Liangdong Sun, Yilv Yan, Peng Zhang, Fan Zhang, Taiwen Li, Chenfei Wang
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Li-Sheng Zhang, Qing-Ping Xiong, Sonia Peña Perez, Chang Liu, Jiangbo Wei, Cassy Le, Linda Zhang, Bryan T. Harada, Qing Dai, Xinran Feng, Ziyang Hao, Yuru Wang, Xueyang Dong, Lulu Hu, En-Duo Wang, Tao Pan, Arne Klungland, Ru-Juan Liu, Chuan He
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages
Shuliang Chen, Sameer Kumar, Constanza E. Espada, Nagaraja Tirumuru, Michael P. Cahill, Lulu Hu, Chuan He, Li Wu
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
Junchao Shi, Yunfang Zhang, Dongmei Tan, Xudong Zhang, Menghong Yan, Ying Zhang, Reuben Franklin, Marta Shahbazi, Kirsty Mackinlay, Shichao Liu, Bernhard Kuhle, Emma R. James, Liwen Zhang, Yongcun Qu, Qiwei Zhai, Wenxin Zhao, Linlin Zhao, Changcheng Zhou, Weifeng Gu, Jernej Murn, Jingtao Guo, Douglas T. Carrell, Yinsheng Wang, Xuemei Chen, Bradley R. Cairns, Xiang-lei Yang, Paul Schimmel, Magdalena Zernicka-Goetz, Sihem Cheloufi, Ying Zhang, Tong Zhou, Qi Chen
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera)
Miao Wang, Yu Xiao, Yan Li, Xiaoying Wang, Suzhen Qi, Ye Wang, Liuwei Zhao, Kai Wang, Wenjun Peng, Guan-Zheng Luo, Xiaofeng Xue, Guifang Jia, Liming Wu
Structure of human RNA polymerase III elongation complex
Liang Li, Zishuo Yu, Dan Zhao, Yulei Ren, Haifeng Hou, Yanhui Xu
Structure of the human RNA polymerase I elongation complex
Dan Zhao, Weida Liu, Ke Chen, Zihan Wu, Huirong Yang, Yanhui Xu
Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine
Haifeng Hou; Yan Li; Mo Wang; Aijun Liu; Zishuo Yu; Ke Chen; Dan Zhao; Yanhui Xu
Integrative analyses of single-cell transcriptome and regulome using MAESTRO
Chenfei Wang, Dongqing Sun, Xin Huang, Changxin Wan, Ziyi Li, Ya Han, Qian Qin, Jingyu Fan, Xintao Qiu, Yingtian Xie, Clifford A. Meyer, Myles Brown, Ming Tang, Henry Long, Tao Liu, X. Shirley Liu
Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer
Min Wang, Jun Liu, Yan Zhao, Ruizhi He, Xiaodong Xu, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng, Yechen Feng, Shuo Yu, Yu Xie, Jianxin Jiang, Min Li, Wenyi Wei, Chuan He, Renyi Qin
Development of mouse preimplantation embryos in space
Xiaohua Lei, Yujing Cao, Baohua Ma, Yunfang Zhang, Lina Ning, Jingjing Qian, Liwen Zhang, Yongcun Qu, Tao Zhang, Dehong Li, Qi Chen, Junchao Shi, Xudong Zhang, Chiyuan Ma, Ying Zhang, Enkui Duan
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine
Ye Wang, Yu Xiao, Shunqing Dong, Qiong Yu, Guifang Jia
Lineage recording of zebrafish embryogenesis reveals historical and ongoing lineage commitments
Chen, Z.; Ye, C.; Liu, Z.; Deng, S.; He, X.; Xu, J.
The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures
Xiaojing Dong, Yan Yan, Bochen Jiang, Yiting Shi, Yuxin Jia, Jinkui Cheng, Yihao Shi, Juqing Kang, Hong Li, Dun Zhang, Lijuan Qi, Run Han, Shaoman Zhang, Yangyang Zhou, Xiaoji Wang, William Terzaghi, Hongya Gu, Dingming Kang, Shuhua Yang, Jigang Li
MYB30 Is a Key Negative Regulator of Arabidopsis Photomorphogenic Development That Promotes PIF4 and PIF5 Protein Accumulation in the Light
Yan Yan, Cong Li, Xiaojing Dong, Hong Li, Dun Zhang, Yangyang Zhou, Bochen Jiang, Jing Peng, Xinyan Qin, Jinkui Cheng, Xiaoji Wang, Pengyu Song, Lijuan Qi, Yuan Zheng, Bosheng Li, William Terzaghi, Shuhua Yang, Yan Guo, Jigang Li
Cold-Induced CBF–PIF3 Interaction Enhances Freezing Tolerance by Stabilizing the phyB Thermosensor in Arabidopsis
Bochen Jiang, Yiting Shi, Yue Peng, Yuxin Jia, Yan Yan, Xiaojing Dong, Hui Li, Jie Dong, Jigang Li, Zhizhong Gong, Michael F. Thomashow, Shuhua Yang
DNA 5-Methylcytosine-Specific Amplification and Sequencing
Chang Liu, Xiaolong Cui, Boxuan Simen Zhao, Pradnya Narkhede, Yawei Gao, Jun Liu, Xiaoyang Dou, Qing Dai, Li-Sheng Zhang, Chuan He
Structure of nucleosome-bound human BAF complex
Shuang He; Zihan Wu; Yuan Tian; Zishuo Yu; Jiali Yu; Xinxin Wang; Jie Li; Bijun Liu; Yanhui Xu
Defining endogenous barcoding sites for CRISPR/Cas9-based cell lineage tracing in zebrafish
Chang Ye, Zhuoxin Chen, Zhan Liu, Feng Wang, Xionglei He
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu, Xiaoyang Dou, Chuanyuan Chen, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao, Dali Han, Chuan He
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu; Xiaoyang Dou; Chuanyuan Chen; Chuan Chen; Chang Liu; Meng Michelle Xu; Siqi Zhao; Bin Shen; Yawei Gao; Dali Han; Chuan He
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
Ziyang Hao, Tong Wu, Xiaolong Cui, Pingping Zhu, Caiping Tan, Xiaoyang Dou, Kai-Wen Hsu, Yueh-Te Lin, Pei-Hua Peng, Li-Sheng Zhang, Yawei Gao, Lulu Hu, Hui-Lung Sun, Allen Zhu, Jianzhao Liu, Kou-Juey Wu, Chuan He
Keth-seq for transcriptome-wide RNA structure mapping
Xiaocheng Weng, Jing Gong, Yi Chen, Tong Wu, Fang Wang, Shixi Yang, Yushu Yuan, Guanzheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang, Xiang Zhou, Chuan He
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
Hai Zheng, Yilun Qi, Shibin Hu, Xuan Cao, Congling Xu, Zhinang Yin, Xizi Chen, Yan Li, Weida Liu, Jie Li, Jiawei Wang, Gang Wei, Kaiwei Liang, Fei Xavier Chen, Yanhui Xu
Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors
Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, Xin Zhiguo Li
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Chuan He, Qiang Xia
Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
Detailed Authors Missing in ORCID
METTL14 is essential for β-cell survival and insulin secretion
Jun Liu, Guanzheng Luo, Juan Sun, Lili Men, Honggang Ye, Chuan He, Decheng Ren
Sperm RNA code programmes the metabolic health of offspring
Yunfang Zhang, Junchao Shi, Minoo Rassoulzadegan, Francesca Tuorto, Qi Chen
Detailed modeling of positive selection improves detection of cancer driver genes
Siming Zhao, Jun Liu, Pranav Nanga, Yuwen Liu, A. Ercument Cicek, Nicholas Knoblauch, Chuan He, Matthew Stephens, Xin He
Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites
Lulu Hu, Yuwen Liu, Shengtong Han, Lei Yang, Xiaolong Cui, Yawei Gao, Qing Dai, Xingyu Lu, Xiaochen Kou, Yanhong Zhao, Wenhui Sheng, Shaorong Gao, Xin He, Chuan He
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA
Li-Sheng Zhang, Chang Liu, Honghui Ma, Qing Dai, Hui-Lung Sun, Guanzheng Luo, Zijie Zhang, Linda Zhang, Lulu Hu, Xueyang Dong, Chuan He
Regulation of Gene Expression by N-methyladenosine in Cancer
Jun Liu, Bryan T. Harada, Chuan He
Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs
Detailed Authors Missing in ORCID
tsRNAs: The Swiss Army Knife for Translational Regulation
Junchao Shi, Yunfang Zhang, Tong Zhou, Qi Chen
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Huilin Huang, Hengyou Weng, Keren Zhou, Tong Wu, Boxuan Simen Zhao, Mingli Sun, Zhenhua Chen, Xiaolan Deng, Gang Xiao, Franziska Auer, Lars Klemm, Huizhe Wu, Zhixiang Zuo, Xi Qin, Yunzhu Dong, Yile Zhou, Hanjun Qin, Shu Tao, Juan Du, Jun Liu, Zhike Lu, Hang Yin, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Wenju Sun, Rui Su, Lei Dong, Chao Shen, Chenying Li, Ying Qing, Xi Jiang, Xiwei Wu, Miao Sun, Jun-Lin Guan, Lianghu Qu, Minjie Wei, Markus Müschen, Gang Huang, Chuan He, Jianhua Yang, Jianjun Chen
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
Xiao Zhang, Lian-Huan Wei, Yuxin Wang, Yu Xiao, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang, Guifang Jia
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
Xiao Zhang, Lian-Huan Wei, Yuxin Wang, Yu Xiao, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang, Guifang Jia
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
Dali Han, Jun Liu, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, Urszula Dougherty, Marc B. Bissonnette, Bin Shen, Ralph R. Weichselbaum, Meng Michelle Xu, Chuan He
Assessing the Influence of Dietary History on Gut Microbiota
Bo Yang, Chang Ye, Bingyu Yan, Xionglei He, Ke Xing
An Elongation‐ and Ligation‐Based qPCR Amplification Method for the Radiolabeling‐Free Detection of Locus‐Specific N6‐Methyladenosine Modification
Yu Xiao, Ye Wang, Qian Tang, Lianhuan Wei, Xiao Zhang, Guifang Jia
Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice†
Jingjing Qian, Yunfang Zhang, Yongcun Qu, Liwen Zhang, Junchao Shi, Xudong Zhang, Shichao Liu, Bo Hyun Kim, Sung Jin Hwang, Tong Zhou, Qi Chen, Sean M Ward, Enkui Duan, Ying Zhang
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos
Rui Gao, Chenfei Wang, Yawei Gao, Wenchao Xiu, Jiayu Chen, Xiaochen Kou, Yanhong Zhao, Yuhan Liao, Dandan Bai, Zhibin Qiao, Lei Yang, Mingzhu Wang, Ruge Zang, Xiaoyu Liu, Yanping Jia, Yanhe Li, Yalin Zhang, Jiqing Yin, Hong Wang, Xiaoping Wan, Wenqiang Liu, Yong Zhang, Shaorong Gao
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
Jun Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu, Kangkang Yu, Samantha M. Tienda, Agnieszka Chryplewicz, Allen C. Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhi-Gao Xu, Xiao-Hua Leng, Xue-Chen Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, Ernst Lengyel, Chuan He
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos
Detailed Authors Missing in ORCID
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Chenfei Wang, Xiaoyu Liu, Yawei Gao, Lei Yang, Chong Li, Wenqiang Liu, Chuan Chen, Xiaochen Kou, Yanhong Zhao, Jiayu Chen, Yixuan Wang, Rongrong Le, Hong Wang, Tao Duan, Yong Zhang, Shaorong Gao
The m 6 A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis
Lian-Huan Wei, Peizhe Song, Ye Wang, Zhike Lu, Qian Tang, Qiong Yu, Yu Xiao, Xiao Zhang, Hong-Chao Duan, Guifang Jia
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Chenfei Wang; Xiaoyu Liu; Yawei Gao; Lei Yang; Chong Li; Wenqiang Liu; Chuan Chen; Xiaochen Kou; Yanhong Zhao; Jiayu Chen; Yixuan Wang; Rongrong Le; Hong Wang; Tao Duan; Yong Zhang; Shaorong Gao
TET-mediated epimutagenesis of the Arabidopsis thaliana methylome
Lexiang Ji, William T. Jordan, Xiuling Shi, Lulu Hu, Chuan He, Robert J. Schmitz
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu
Target-triggered transcription machinery for ultra-selective and sensitive fluorescence detection of nucleoside triphosphates in one minute
Jiantong Dong, Tongbo Wu, Yu Xiao, Lu Chen, Lei Xu, Mengyuan Li, Meiping Zhao
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
Yunfang Zhang, Xudong Zhang, Junchao Shi, Francesca Tuorto, Xin Li, Yusheng Liu, Reinhard Liebers, Liwen Zhang, Yongcun Qu, Jingjing Qian, Maya Pahima, Ying Liu, Menghong Yan, Zhonghong Cao, Xiaohua Lei, Yujing Cao, Hongying Peng, Shichao Liu, Yue Wang, Huili Zheng, Rebekah Woolsey, David Quilici, Qiwei Zhai, Lei Li, Tong Zhou, Wei Yan, Frank Lyko, Ying Zhang, Qi Zhou, Enkui Duan, Qi Chen
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Detailed Authors Missing in ORCID
tsRNAs: new players in mammalian retrotransposon control
Yunfang Zhang, Junchao Shi, Qi Chen
Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing
Wei Wang, Liang Xu, Lulu Hu, Jenny Chong, Chuan He, Dong Wang
PIF3 is a negative regulator of theCBFpathway and freezing tolerance inArabidopsis
Bochen Jiang, Yiting Shi, Xiaoyan Zhang, Xiaoyun Xin, Lijuan Qi, Hongwei Guo, Jigang Li, Shuhua Yang
Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study
Xiu-Wen Tan, Chang-Li Ji, Liang-Liang Zheng, Jie Zhang, Hong-Jie Yuan, Shuai Gong, Jiang Zhu, Jing-He Tan
Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes
Tian-Yang Wang, Jie Zhang, Jiang Zhu, Hua-Yu Lian, Hong-Jie Yuan, Min Gao, Ming-Jiu Luo, Jing-He Tan
CDX2 is essential for cell proliferation and polarity in porcine blastocysts
Gerelchimeg Bou, Shichao Liu, Mingju Sun, Jiang Zhu, Binghua Xue, Jia Guo, Yueming Zhao, Bo Qu, Xiaogang Weng, Yanchang Wei, Lei Lei, Zhonghua Liu
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Xiaoyu Liu, Chenfei Wang, Wenqiang Liu, Jingyi Li, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang, Yawei Gao, Shaorong Gao
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Xiaoyu Liu, Chenfei Wang, Wenqiang Liu, Jingyi Li, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang, Yawei Gao, Shaorong Gao
The relationship between apoptosis, chromatin configuration, histone modification and competence of oocytes: A study using the mouse ovary-holding stress model
Juan Lin, Fei Chen, Ming-Ju Sun, Jiang Zhu, You-Wei Li, Liu-Zhu Pan, Jie Zhang, Jing-He Tan
The relationship between apoptosis, chromatin configuration, histone modification and competence of oocytes: A study using the mouse ovary-holding stress model
Juan Lin, Fei Chen, Ming-Ju Sun, Jiang Zhu, You-Wei Li, Liu-Zhu Pan, Jie Zhang, Jing-He Tan
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing
Wenqiang Liu, Xiaoyu Liu, Chenfei Wang, Yawei Gao, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang, Shaorong Gao
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.
Detailed Authors Missing in ORCID
Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
Junchao Shi, Yunfang Zhang, Qi Chen
A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2)
Junyan Lu, Lulu Hu, Jingdong Cheng, Dong Fang, Chen Wang, Kunqian Yu, Hualiang Jiang, Qiang Cui, Yanhui Xu, Cheng Luo
The signaling pathways by which the Fas/FasL system accelerates oocyte aging
Jiang Zhu, Fei-Hu Lin, Jie Zhang, Juan Lin, Hong Li, You-Wei Li, Xiu-Wen Tan, Jing-He Tan
Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos
Yan Jun HUAN, Zhan Feng WU, Ji Guang ZHANG, Jiang ZHU, Bing Teng XIE, Jian Yu WANG, Jing Yu LI, Bing Hua XUE, Qing Ran KONG, Zhong Hua LIU
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Qi Chen, Menghong Yan, Zhonghong Cao, Xin Li, Yunfang Zhang, Junchao Shi, Gui-hai Feng, Hongying Peng, Xudong Zhang, Ying Zhang, Jingjing Qian, Enkui Duan, Qiwei Zhai, Qi Zhou
A fuel-limited isothermal DNA machine for the sensitive detection of cellular deoxyribonucleoside triphosphates
Jiantong Dong, Tongbo Wu, Yu Xiao, Lei Xu, Simin Fang, Meiping Zhao
Ovulation Statuses of Surrogate Gilts Are Associated with the Efficiency of Excellent Pig Cloning
Yanjun Huan, Kui Hu, Bingteng Xie, Yongqian Shi, Feng Wang, Yang Zhou, Shichao Liu, Bo Huang, Jiang Zhu, Zhongfeng Liu, Yilong He, Jingyu Li, Qingran Kong, Zhonghua Liu
Effect of Short-Term Hypergravity Treatment on Mouse 2-Cell Embryo Development
Li-Na Ning, Xiao-Hua Lei, Yu-Jing Cao, Yun-Fang Zhang, Zhong-Hong Cao, Qi Chen, En-Kui Duan
Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos
Yanjun Huan, Zhanfeng Wu, Jiguang Zhang, Jiang Zhu, Zhonghua Liu, Xuexiong Song
Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs
Yanjun Huan, Hongmei Wang, Zhanfeng Wu, Jiguang Zhang, Jiang Zhu, Zhonghua Liu, Hongbin He
Trichostatin A Rescues the Disrupted Imprinting Induced by Somatic Cell Nuclear Transfer in Pigs
Yanjun Huan, Jiang Zhu, Bo Huang, Yanshuang Mu, Qingran Kong, Zhonghua Liu
The Combination of Tet1 with Oct4 Generates High-Quality Mouse-Induced Pluripotent Stem Cells
Jiayu Chen, Yawei Gao, Hua Huang, Kai Xu, Xia Chen, Yonghua Jiang, Hui Li, Shuai Gao, Yu Tao, Hong Wang, Yong Zhang, Hailin Wang, Tao Cai, Shaorong Gao
Structural insight into substrate preference for TET-mediated oxidation
Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo, Yanhui Xu
Cumulus cells accelerate oocyte aging by releasing soluble Fas Ligand in mice
Jiang Zhu, Jie Zhang, Hong Li, Tian-Yang Wang, Chuan-Xin Zhang, Ming-Jiu Luo, Jing-He Tan
Unique features of the m6A methylome in Arabidopsis thaliana
Guan-Zheng Luo, Alice MacQueen, Guanqun Zheng, Hongchao Duan, Louis C. Dore, Zhike Lu, Jun Liu, Kai Chen, Guifang Jia, Joy Bergelson, Chuan He
Xist Deficiency and Disorders of X-Inactivation in Rabbit Embryonic Stem Cells Can Be Rescued by Transcription-Factor-Mediated Conversion
Yonghua Jiang, Zhaohui Kou, Tong Wu, Weidong An, Ran Zhou, Hong Wang, Yawei Gao, Shaorong Gao
Quality Control: H2A.X Links to Better iPSCs
Yawei Gao, Shaorong Gao
A pre-breeding screening program for transgenic boars based on fluorescence in situ hybridization assay
Gerelchimeg Bou, Mingju Sun, Ming Lv, Jiang Zhu, Hui Li, Juan Wang, Lu Li, Zhongfeng Liu, Zhong Zheng, Wenteng He, Qingran Kong, Zhonghua Liu
A new turn-on fluorescence probe for Zn2+ in aqueous solution and imaging application in living cells
Meng-Meng Li, Fang-Wu Wang, Xiao-Yun Wang, Ting-Ting Zhang, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao
Role of Na+/Ca2+ Exchanger (NCX) in Modulating Postovulatory Aging of Mouse and Rat Oocytes
Chuan-Xin Zhang, Wei Cui, Min Zhang, Jie Zhang, Tian-Yang Wang, Jiang Zhu, Guang-Zhong Jiao, Jing-He Tan
Non-frozen preservation protocols for mature mouse oocytes dramatically extend their developmental competence by reducing oxidative stress
T.-Y. Wang, Q. Li, Q. Li, H. Li, J. Zhu, W. Cui, G.-Z. Jiao, J.-H. Tan
Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection
Yunfang Zhang, Ying Zhang, Junchao Shi, He Zhang, Zhonghong Cao, Xuan Gao, Wanhua Ren, Yunna Ning, Lina Ning, Yujing Cao, Yongchang Chen, Weizhi Ji, Zi-jiang Chen, Qi Chen, Enkui Duan
A new fluorescent pH probe for extremely acidic conditions
Yu Xu, Zheng Jiang, Yu Xiao, Fu-Zhen Bi, Jun-Ying Miao, Bao-Xiang Zhao
Epigenetic Modification Agents Improve Genomic Methylation Reprogramming in Porcine Cloned Embryos
Yan Jun HUAN, Jiang ZHU, Hong Mei WANG, Zhan Feng WU, Ji Guang ZHANG, Bing Teng XIE, Jing Yu LI, Qing Ran KONG, Zhong Hua LIU, Hong Bin HE
Methylation Modifications in Eukaryotic Messenger RNA
Jun Liu, Guifang Jia
A new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms
Yu Xu, Zheng Jiang, Yu Xiao, Ting-Ting Zhang, Jun-Ying Miao, Bao-Xiang Zhao
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Lulu Hu, Ze Li, Jingdong Cheng, Qinhui Rao, Wei Gong, Mengjie Liu, Yujiang Geno Shi, Jiayu Zhu, Ping Wang, Yanhui Xu
A New Thiophenyl Pyrazoline Fluorescent Probe for Cu2+ in Aqueous Solution and Imaging in Live Cell
Meng-Meng Li, Wen-Bo Zhao, Ting-Ting Zhang, Wei-Liu Fan, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis
Haiyun Gan, Lu Wen, Shangying Liao, Xiwen Lin, Tingting Ma, Jun Liu, Chun-xiao Song, Min Wang, Chuan He, Chunsheng Han, Fuchou Tang
Hormonal Regulation of Ovarian Bursa Fluid in Mice and Involvement of Aquaporins
He Zhang, Ying Zhang, Huashan Zhao, Yunfang Zhang, Qi Chen, Hongying Peng, Li Lei, Jingqiao Qiao, Junchao Shi, Zhonghong Cao, Enkui Duan, Yaping Jin
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
Yawei Gao, Jiayu Chen, Ke Li, Tong Wu, Bo Huang, Wenqiang Liu, Xiaochen Kou, Yu Zhang, Hua Huang, Yonghua Jiang, Chao Yao, Xiaolei Liu, Zhiwei Lu, Zijian Xu, Lan Kang, Jun Chen, Hailin Wang, Tao Cai, Shaorong Gao
Treating Cloned Embryos, But Not Donor Cells, with 5-aza-2’-deoxycytidine Enhances the Developmental Competence of Porcine Cloned Embryos
Yan Jun HUAN, Jiang ZHU, Bing Teng XIE, Jian Yu WANG, Shi Chao LIU, Yang ZHOU, Qing Ran KONG, Hong Bin HE, Zhong Hua LIU
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng, John Arne Dahl, Yamei Niu, Peter Fedorcsak, Chun-Min Huang, Charles J. Li, Cathrine B. Vågbø, Yue Shi, Wen-Ling Wang, Shu-Hui Song, Zhike Lu, Ralph P.G. Bosmans, Qing Dai, Ya-Juan Hao, Xin Yang, Wen-Ming Zhao, Wei-Min Tong, Xiu-Jie Wang, Florian Bogdan, Kari Furu, Ye Fu, Guifang Jia, Xu Zhao, Jun Liu, Hans E. Krokan, Arne Klungland, Yun-Gui Yang, Chuan He
Overexpression Nanog Activates Pluripotent Genes in Porcine Fetal Fibroblasts and Nuclear Transfer Embryos
Li Zhang, Yi‐Bo Luo, Gerelchimeg Bou, Qing‐Ran Kong, Yan‐Jun Huan, Jiang Zhu, Jian‐Yu Wang, Hui Li, Feng Wang, Yong‐Qian Shi, Yan‐Chang Wei, Zhong‐Hua Liu
A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance
Meng Zhang, Shixian Lin, Xinwen Song, Jun Liu, Ye Fu, Xi Ge, Xinmiao Fu, Zengyi Chang, Peng R Chen
TSA improve transgenic porcine cloned embryo development and transgene expression
Qing-Ran KONG, Jiang ZHU, Bo HUANG, Yan-Jun HUAN, Feng WANG, Yong-Qian SHI, Zhong-Feng LIU, Mei-Ling WU, Zhong-Hua LIU
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
Lulu Hu, Ze Li, Ping Wang, Yan Lin, Yanhui Xu
PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression
Eerappa Rajakumara, Zhentian Wang, Honghui Ma, Lulu Hu, Hao Chen, Yan Lin, Rui Guo, Feizhen Wu, Haitao Li, Fei Lan, Yujiang Geno Shi, Yanhui Xu, Dinshaw J. Patel, Yang Shi
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Ying Yang, Lulu Hu, Ping Wang, Haifeng Hou, Yan Lin, Yi Liu, Ze Li, Rui Gong, Xiang Feng, Lu Zhou, Wen Zhang, Yuhui Dong, Huirong Yang, Hanqing Lin, Yiqin Wang, Charlie Degui Chen, Yanhui Xu
Aberrant Expression and Methylation Status of Putatively Imprinted Genes in Placenta of Cloned Piglets
Yanchang Wei, Jiang Zhu, Yanjun Huan, Zhongfeng Liu, Cairong Yang, Xinmiao Zhang, Yanshuang Mu, Ping Xia, Zhouhua Liu
Metal-Driven Hierarchical Self-Assembled One-Dimensional Nanohelices
Yan Qiao, Yiyang Lin, Yijie Wang, Zhiyi Yang, Jun Liu, Jiang Zhou, Yun Yan, Jianbin Huang
Structural insight into substrate preference for TET-mediated oxidation
Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo, Yanhui Xu
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Lulu Hu, Ze Li, Jingdong Cheng, Qinhui Rao, Wei Gong, Mengjie Liu, Yujiang Geno Shi, Jiayu Zhu, Ping Wang, Yanhui Xu
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
Lulu Hu, Ze Li, Ping Wang, Yan Lin, Yanhui Xu
PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression
Eerappa Rajakumara, Zhentian Wang, Honghui Ma, Lulu Hu, Hao Chen, Yan Lin, Rui Guo, Feizhen Wu, Haitao Li, Fei Lan, Yujiang Geno Shi, Yanhui Xu, Dinshaw J. Patel, Yang Shi
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Ying Yang, Lulu Hu, Ping Wang, Haifeng Hou, Yan Lin, Yi Liu, Ze Li, Rui Gong, Xiang Feng, Lu Zhou, Wen Zhang, Yuhui Dong, Huirong Yang, Hanqing Lin, Yiqin Wang, Charlie Degui Chen, Yanhui Xu