研究介绍
研究方向：
1、研究父系获得性性状代际/跨代遗传中基于非编码小 RNA的分子调控网络；
2、探究小 RNA 在精子发生及成熟过程中的功能及调控机制；
3、 解析tsRNA及RNA修饰参与早期胚胎发育的作用及机制；
4、 挖掘RNA修饰参与tRNA功能调控及tsRNA生物合成的机制；
团队成员
张云芳
Principal Investigator
发表论文
2025
NAT10 primes a post-transcriptional repertoire essential for the maintenance of spermatogonial homeostasis
Xiaoli Zhu, Caoling Xu, Xue Jiang, Jiaqi Zou, Wenqing Li, Xuemei Xing, Xiaoxiao Gao, Jiao Lei, Fei Meng, Xin Wang, Yuzhang Zhu, Yu Cheng, Muhammad Azhar, Wenjie Han, Ge Lin, Yunfang Zhang, Ge Shan, Shen Zhang, Jianqiang Bao
Science Bulletin
DOI
2025
METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m6A methylation in humans and mice
Mengya Zhang, Xueguang Zhang, Chen Tan, Ting Jiang, Zheng Cao, Yufei Chen, Feng Qiao, Gelin Huang, Chaoye Ma, Huixia Li, Mei Ye, Lei Wang, Liandong Zuo, Jun Yu, Xiaofeng Li, Yunfang Zhang, Yue-Qiu Tan, Shuibin Lin, Wenming Xu, Hao Chen
Molecular Therapy
DOI
2025
Hypoxia exposure impairs male fertility via inhibiting Septin2-mediated spermatogonial proliferation
Zhibin Li, Shuying Li, Yufeng Xiao, Junfeng Guo, Jianchun Zhou, Yang Chen, Juan Yang, Chunli Gong, Bing He, Yuyun Wu, Nannan Gao, Huan Yang, Limin Gao, Hua Hu, Yunfang Zhang, Shiming Yang
Human Reproduction Open
DOI
2025
Optimized identification and characterization of small RNAs with PANDORA-seq
Junchao Shi, Yunfang Zhang, Yun Li, Liwen Zhang, Xudong Zhang, Menghong Yan, Qi Chen, Ying Zhang
Nature Protocols
DOI
2024
METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control
Pan Zhao, Lin Xia, Dan Chen, Wei Xu, Huanping Guo, Yinying Xu, Bingbing Yan, Xiao Wu, Yuxia Li, Yunfang Zhang, Xi Zhang
Experimental Hematology & Oncology
DOI
2024
tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators
Yun Li, Zongyu Yu, Wenlin Jiang, Xinyi Lyu, Ailian Guo, Xiaorui Sun, Yiting Yang, Yunfang Zhang
Biomolecules
DOI
2023
Hypoxia induces alterations in tRNA modifications involved in translational control
Huanping Guo, Lin Xia, Wei Wang, Wei Xu, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang, Yunfang Zhang
BMC Biology
DOI
2023
Human circulating small non-coding RNA signature as a non-invasive biomarker in clinical diagnosis of acute myeloid leukaemia
Lin Xia, Huanping Guo, Xiao Wu, Yinying Xu, Pan Zhao, Bingbing Yan, Yunjing Zeng, Yundi He, Dan Chen, Robert Peter Gale, Yunfang Zhang, Xi Zhang
Theranostics
DOI
2022
Alteration of RNA modification signature in human sperm correlates with sperm motility
Huanping Guo, Xipeng Shen, Hua Hu, Peng Zhou, Tong He, Lin Xia, Dongmei Tan, Xi Zhang, Yunfang Zhang
Molecular Human Reproduction
DOI
2022
Alterations of RNA Modification in Mouse Germ Cell-2 Spermatids Under Hypoxic Stress
Tong He, Huanping Guo, Lin Xia, Xipeng Shen, Yun Huang, Xiao Wu, Xuelin Jiang, Yinying Xu, Yi Tan, Yunfang Zhang, Dongmei Tan
Frontiers in Molecular Biosciences
DOI
2022
Paternal High-Fat Diet Altered Sperm 5'tsRNA-Gly-GCC Is Associated With Enhanced Gluconeogenesis in the Offspring
Bin Wang, Lin Xia, Dan Zhu, Hongtao Zeng, Bin Wei, Likui Lu, Weisheng Li, Yajun Shi, Jingliu Liu, Yunfang Zhang, Miao Sun
Frontiers in Molecular Biosciences
DOI
2021
Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity
Zheng Wang, Chengyan Chai, Rui Wang, Yimei Feng, Lei Huang, Yiming Zhang, Xia Xiao, Shijie Yang, Yunfang Zhang, Xi Zhang
Clinical and Translational Medicine
DOI
2021
Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm
Tong He, Huanping Guo, Xipeng Shen, Xiao Wu, Lin Xia, Xuelin Jiang, Yinying Xu, Dan Chen, Yunfang Zhang, Dongmei Tan, Yi Tan
Biology of Reproduction
DOI
2021
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
Junchao Shi, Yunfang Zhang, Dongmei Tan, Xudong Zhang, Menghong Yan, Ying Zhang, Reuben Franklin, Marta Shahbazi, Kirsty Mackinlay, Shichao Liu, Bernhard Kuhle, Emma R. James, Liwen Zhang, Yongcun Qu, Qiwei Zhai, Wenxin Zhao, Linlin Zhao, Changcheng Zhou, Weifeng Gu, Jernej Murn, Jingtao Guo, Douglas T. Carrell, Yinsheng Wang, Xuemei Chen, Bradley R. Cairns, Xiang-lei Yang, Paul Schimmel, Magdalena Zernicka-Goetz, Sihem Cheloufi, Ying Zhang, Tong Zhou, Qi Chen
Nature Cell Biology
DOI
2020
Development of mouse preimplantation embryos in space
Xiaohua Lei, Yujing Cao, Baohua Ma, Yunfang Zhang, Lina Ning, Jingjing Qian, Liwen Zhang, Yongcun Qu, Tao Zhang, Dehong Li, Qi Chen, Junchao Shi, Xudong Zhang, Chiyuan Ma, Ying Zhang, Enkui Duan
National Science Review
DOI
2019
Sperm RNA code programmes the metabolic health of offspring
Yunfang Zhang, Junchao Shi, Minoo Rassoulzadegan, Francesca Tuorto, Qi Chen
Nature Reviews Endocrinology
DOI
2019
tsRNAs: The Swiss Army Knife for Translational Regulation
Junchao Shi, Yunfang Zhang, Tong Zhou, Qi Chen
Trends in Biochemical Sciences
DOI
2018
Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice†
Jingjing Qian, Yunfang Zhang, Yongcun Qu, Liwen Zhang, Junchao Shi, Xudong Zhang, Shichao Liu, Bo Hyun Kim, Sung Jin Hwang, Tong Zhou, Qi Chen, Sean M Ward, Enkui Duan, Ying Zhang
Biology of Reproduction
DOI
2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
Yunfang Zhang, Xudong Zhang, Junchao Shi, Francesca Tuorto, Xin Li, Yusheng Liu, Reinhard Liebers, Liwen Zhang, Yongcun Qu, Jingjing Qian, Maya Pahima, Ying Liu, Menghong Yan, Zhonghong Cao, Xiaohua Lei, Yujing Cao, Hongying Peng, Shichao Liu, Yue Wang, Huili Zheng, Rebekah Woolsey, David Quilici, Qiwei Zhai, Lei Li, Tong Zhou, Wei Yan, Frank Lyko, Ying Zhang, Qi Zhou, Enkui Duan, Qi Chen
Nature Cell Biology
DOI
2017
tsRNAs: new players in mammalian retrotransposon control
Yunfang Zhang, Junchao Shi, Qi Chen
Cell Research
DOI
2016
Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
Junchao Shi, Yunfang Zhang, Qi Chen
Environmental Epigenetics
DOI
2016
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Qi Chen, Menghong Yan, Zhonghong Cao, Xin Li, Yunfang Zhang, Junchao Shi, Gui-hai Feng, Hongying Peng, Xudong Zhang, Ying Zhang, Jingjing Qian, Enkui Duan, Qiwei Zhai, Qi Zhou
Science
DOI
2015
Effect of Short-Term Hypergravity Treatment on Mouse 2-Cell Embryo Development
Li-Na Ning, Xiao-Hua Lei, Yu-Jing Cao, Yun-Fang Zhang, Zhong-Hong Cao, Qi Chen, En-Kui Duan
Microgravity Science and Technology
DOI
2014
Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection
Yunfang Zhang, Ying Zhang, Junchao Shi, He Zhang, Zhonghong Cao, Xuan Gao, Wanhua Ren, Yunna Ning, Lina Ning, Yujing Cao, Yongchang Chen, Weizhi Ji, Zi-jiang Chen, Qi Chen, Enkui Duan
Journal of Molecular Cell Biology
DOI
2013
Hormonal Regulation of Ovarian Bursa Fluid in Mice and Involvement of Aquaporins
He Zhang, Ying Zhang, Huashan Zhao, Yunfang Zhang, Qi Chen, Hongying Peng, Li Lei, Jingqiao Qiao, Junchao Shi, Zhonghong Cao, Enkui Duan, Yaping Jin
PLoS ONE
DOI
联系方式
张云芳 Lab
Sycamore Research Institute of Life Sciences
上海市浦东新区张江路88号
上海梧桐岛生命科学研究院