研究介绍
细胞表面蛋白高灵敏度定量检测，绘制肿瘤微环境 RNA 修饰图谱。
团队成员
胡璐璐
Principal Investigator
发表论文
2025
Deciphering the RNA landscapes on mammalian cell surfaces
Xiao Jiang, Chu Xu, Enzhuo Yang, Danhua Xu, Yong Peng, Xue Han, Jingwen Si, Qixin Shao, Zhuo Liu, Qiuxiao Chen, Weizhi He, Shuang He, Yanhui Xu, Chuan He, Xinxin Huang, Lulu Hu
Protein & Cell
DOI
2025
Profiling RNA subcellular localization in situ by TATA-seq
Junjie Li, Chu Xu, Xiao Jiang, Xinxin Huang, Dan Ye, LuLu Hu
RNA
DOI
2025
LAMP‐MS for Locus‐Specific Visual Quantification of DNA 5 mC and RNA m6A Using Ultra‐Low Input
Runyu Xie, Xiaotong Yang, Weizhi He, Zhongguang Luo, Wenshuai Li, Chu Xu, Xiaolong Cui, Wei Zhang, Ning Wei, Xiaolan Wang, Yixiang Shi, Chuan He, Jie Liu, Lulu Hu
Angewandte Chemie International Edition
DOI
2025
Uli-epic: profiling RNA modifications from ultra-low input samples
Weizhi He, Chu Xu, Wen Chen, Xiao Jiang, Yuhang Wang, Yong Peng, Shujuan Chang, Wei Zhu, Jiuhong Kang, Lulu Hu
Genome Biology
DOI
2024
Exploring transient global transcriptional changes induced by ascorbic acid revealed via atKAS-seq profiling
Xiangyue Liu, Weizhi He, Lulu Hu
Functional & Integrative Genomics
DOI
2024
Ascorbic Acid Reprograms Epigenome and Epitranscriptome by Reducing Fe(III) in the Catalytic Cycle of Dioxygenases
Weizhi He, Xiaotong Yin, Chu Xu, Xiangyue Liu, Yue Huang, Caiguang Yang, Yanhui Xu, Lulu Hu
ACS Chemical Biology
DOI
2023
m6A-SAC-seq for quantitative whole transcriptome m6A profiling
Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu, Chuan He
Nature Protocols
DOI
2023
scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang
Nature Communications
DOI
2022
Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing
Yong Peng, Hanzhe Meng, Ruiqi Ge, Shun Liu, Mengjie Chen, Chuan He, Lulu Hu
STAR Protocols
DOI
2022
Quantitative and single nucleotide RNA m6A detection technology boosts clinical research based on tissue and cell free RNA modification
Lulu Hu
Clinical and Translational Medicine
DOI
2022
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Rui Su, Chamara Senevirathne, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang, Minkui Luo, Mengjie Chen, Jianjun Chen, Chuan He
Nature Biotechnology
DOI
2021
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages
Shuliang Chen, Sameer Kumar, Constanza E. Espada, Nagaraja Tirumuru, Michael P. Cahill, Lulu Hu, Chuan He, Li Wu
PLOS Pathogens
DOI
2021
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Li-Sheng Zhang, Qing-Ping Xiong, Sonia Peña Perez, Chang Liu, Jiangbo Wei, Cassy Le, Linda Zhang, Bryan T. Harada, Qing Dai, Xinran Feng, Ziyang Hao, Yuru Wang, Xueyang Dong, Lulu Hu, En-Duo Wang, Tao Pan, Arne Klungland, Ru-Juan Liu, Chuan He
Nature Cell Biology
DOI
2020
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
Ziyang Hao, Tong Wu, Xiaolong Cui, Pingping Zhu, Caiping Tan, Xiaoyang Dou, Kai-Wen Hsu, Yueh-Te Lin, Pei-Hua Peng, Li-Sheng Zhang, Yawei Gao, Lulu Hu, Hui-Lung Sun, Allen Zhu, Jianzhao Liu, Kou-Juey Wu, Chuan He
Molecular Cell
DOI
2020
Keth-seq for transcriptome-wide RNA structure mapping
Xiaocheng Weng, Jing Gong, Yi Chen, Tong Wu, Fang Wang, Shixi Yang, Yushu Yuan, Guanzheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang, Xiang Zhou, Chuan He
Nature Chemical Biology
DOI
2019
Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites
Lulu Hu, Yuwen Liu, Shengtong Han, Lei Yang, Xiaolong Cui, Yawei Gao, Qing Dai, Xingyu Lu, Xiaochen Kou, Yanhong Zhao, Wenhui Sheng, Shaorong Gao, Xin He, Chuan He
Journal of the American Chemical Society
DOI
2019
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA
Li-Sheng Zhang, Chang Liu, Honghui Ma, Qing Dai, Hui-Lung Sun, Guanzheng Luo, Zijie Zhang, Linda Zhang, Lulu Hu, Xueyang Dong, Chuan He
Molecular Cell
DOI
2018
TET-mediated epimutagenesis of the Arabidopsis thaliana methylome
Lexiang Ji, William T. Jordan, Xiuling Shi, Lulu Hu, Chuan He, Robert J. Schmitz
Nature Communications
DOI
2017
Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing
Wei Wang, Liang Xu, Lulu Hu, Jenny Chong, Chuan He, Dong Wang
Journal of the American Chemical Society
DOI
2016
A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2)
Junyan Lu, Lulu Hu, Jingdong Cheng, Dong Fang, Chen Wang, Kunqian Yu, Hualiang Jiang, Qiang Cui, Yanhui Xu, Cheng Luo
Physical Chemistry Chemical Physics
DOI
2015
2015
Structural insight into substrate preference for TET-mediated oxidation
Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo, Yanhui Xu
Nature
DOI
2013
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Lulu Hu, Ze Li, Jingdong Cheng, Qinhui Rao, Wei Gong, Mengjie Liu, Yujiang Geno Shi, Jiayu Zhu, Ping Wang, Yanhui Xu
Cell
DOI
2011
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
Lulu Hu, Ze Li, Ping Wang, Yan Lin, Yanhui Xu
Cell Research
DOI
2011
PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression
Eerappa Rajakumara, Zhentian Wang, Honghui Ma, Lulu Hu, Hao Chen, Yan Lin, Rui Guo, Feizhen Wu, Haitao Li, Fei Lan, Yujiang Geno Shi, Yanhui Xu, Dinshaw J. Patel, Yang Shi
Molecular Cell
DOI
2010
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Ying Yang, Lulu Hu, Ping Wang, Haifeng Hou, Yan Lin, Yi Liu, Ze Li, Rui Gong, Xiang Feng, Lu Zhou, Wen Zhang, Yuhui Dong, Huirong Yang, Hanqing Lin, Yiqin Wang, Charlie Degui Chen, Yanhui Xu
Cell Research
DOI
联系方式
胡璐璐 Lab
Sycamore Research Institute of Life Sciences
上海市浦东新区张江路88号
上海梧桐岛生命科学研究院