研究介绍
染色质调控，非编码小RNA的功能，组学新技术开发，高时空分辨率RNA测序
团队成员
肖雨
Principal Investigator
发表论文
2024
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Zhongyu Zou, Xiaoyang Dou, Ying Li, Zijie Zhang, Juan Wang, Boyang Gao, Yu Xiao, Yiding Wang, Lijie Zhao, Chenxi Sun, Qinzhe Liu, Xianbin Yu, Hao Wang, Juyeong Hong, Qing Dai, Feng-Chun Yang, Mingjiang Xu, Chuan He
Nature
DOI
2024
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency
Jinjun Wu, Yu Xiao, Yunzheng Liu, Li Wen, Chuanyang Jin, Shun Liu, Sneha Paul, Chuan He, Oded Regev, Jingyi Fei
Science Advances
DOI
2024
IGF2BP3 promotes mRNA degradation through internal m7G modification
Chang Liu, Xiaoyang Dou, Yutao Zhao, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan He
Nature Communications
DOI
2024
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
Yu Xiao, Yan-Ming Chen, Zhongyu Zou, Chang Ye, Xiaoyang Dou, Jinjun Wu, Chang Liu, Shun Liu, Hao Yan, Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu, Jingyi Fei, Weixin Tang, Chuan He
Nature Methods
DOI
2023
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity
Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu
Protein & Cell
DOI
2023
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Xiaoyang Dou, Yu Xiao, Chao Shen, Kitty Wang, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan He
Nature Cell Biology
DOI
2023
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He, Shuying Sun
Nature Neuroscience
DOI
2021
RNA demethylation increases the yield and biomass of rice and potato plants in field trials
Qiong Yu, Shun Liu, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song, Chuan He, Guifang Jia
Nature Biotechnology
DOI
2021
LEAD‐m6A‐seq for Locus‐Specific Detection of N6‐Methyladenosine and Quantification of Differential Methylation
Yuru Wang, Zijie Zhang, Caraline Sepich‐Poore, Lisheng Zhang, Yu Xiao, Chuan He
Angewandte Chemie International Edition
DOI
2021
RNA m6A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera)
Miao Wang, Yu Xiao, Yan Li, Xiaoying Wang, Suzhen Qi, Ye Wang, Liuwei Zhao, Kai Wang, Wenjun Peng, Guan-Zheng Luo, Xiaofeng Xue, Guifang Jia, Liming Wu
Cell Reports
DOI
2020
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine
Ye Wang, Yu Xiao, Shunqing Dong, Qiong Yu, Guifang Jia
Nature Chemical Biology
DOI
2019
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
Xiao Zhang, Lian-Huan Wei, Yuxin Wang, Yu Xiao, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang, Guifang Jia
Proceedings of the National Academy of Sciences
DOI
2018
An Elongation‐ and Ligation‐Based qPCR Amplification Method for the Radiolabeling‐Free Detection of Locus‐Specific N6‐Methyladenosine Modification
Yu Xiao, Ye Wang, Qian Tang, Lianhuan Wei, Xiao Zhang, Guifang Jia
Angewandte Chemie International Edition
DOI
2018
The m 6 A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis
Lian-Huan Wei, Peizhe Song, Ye Wang, Zhike Lu, Qian Tang, Qiong Yu, Yu Xiao, Xiao Zhang, Hong-Chao Duan, Guifang Jia
The Plant Cell
DOI
2018
Target-triggered transcription machinery for ultra-selective and sensitive fluorescence detection of nucleoside triphosphates in one minute
Jiantong Dong, Tongbo Wu, Yu Xiao, Lu Chen, Lei Xu, Mengyuan Li, Meiping Zhao
Biosensors and Bioelectronics
DOI
2016
A fuel-limited isothermal DNA machine for the sensitive detection of cellular deoxyribonucleoside triphosphates
Jiantong Dong, Tongbo Wu, Yu Xiao, Lei Xu, Simin Fang, Meiping Zhao
Chemical Communications
DOI
2014
A new turn-on fluorescence probe for Zn2+ in aqueous solution and imaging application in living cells
Meng-Meng Li, Fang-Wu Wang, Xiao-Yun Wang, Ting-Ting Zhang, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao
Analytica Chimica Acta
DOI
2014
A new fluorescent pH probe for extremely acidic conditions
Yu Xu, Zheng Jiang, Yu Xiao, Fu-Zhen Bi, Jun-Ying Miao, Bao-Xiang Zhao
Analytica Chimica Acta
DOI
2014
A new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms
Yu Xu, Zheng Jiang, Yu Xiao, Ting-Ting Zhang, Jun-Ying Miao, Bao-Xiang Zhao
Analytica Chimica Acta
DOI
2013
A New Thiophenyl Pyrazoline Fluorescent Probe for Cu2+ in Aqueous Solution and Imaging in Live Cell
Meng-Meng Li, Wen-Bo Zhao, Ting-Ting Zhang, Wei-Liu Fan, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao
Journal of Fluorescence
DOI
联系方式
肖雨 Lab
Sycamore Research Institute of Life Sciences
上海市浦东新区张江路88号
上海梧桐岛生命科学研究院