Research Progress

Research Highlights

Tracking the latest discoveries and breakthroughs in life sciences at SRILS.

2026.03.01 | RESEARCH

Genome Biology | 王晨飞课题组开发单细胞分辨率的跨模态生成算法Cisformer解析转录调控机制

上海梧桐岛生命科学研究院客座研究员王晨飞团队提出用于单细胞分辨率的基因表达与染色质可及性数据生成的人工智能模型。

2026.02.08 | RESEARCH

Genome Medicine | 王晨飞课题组开发单细胞代谢状态及调控因子预测算法MetroSCREEN

上海梧桐岛生命科学研究院客座研究员王晨飞团队提出一种可用于识别代谢亚型及其上游调控因子的方法。

2026.02.05 | RESEARCH

Cell Rep | Yawei Gao's Team at SRILS Establishes an Efficient Differentiation Scheme for LGE/CGE-type GABAergic Neurons

Yawei Gao's team at the Sycamore Research Institute of Life Sciences (SRILS) published a study in Cell Reports, establishing a novel and efficient scheme for differentiating induced pluripotent stem cells into LGE/CGE-type GABAergic neurons, providing a vital resource for cell therapy of neurological diseases.

2026.01.22 | RESEARCH

Cell | Jun Liu's Team Develops FOCAS Platform for Transcriptome-wide Functional Analysis of m6A Sites

Published in Cell, Jun Liu's team developed the FOCAS platform based on CRISPR-dCas13b-FTO. This enables transcriptome-wide functional screening of m6A sites with single-base precision, revealing extensive regulatory networks of m6A in cancer cell proliferation.

2025.10.29 | RESEARCH

Cell Stem Cell | Teams of Yawei Gao and Jun Liu Reveal Mechanism of m⁶A-mediated LTR Silencing and Totipotency Restriction via L1PA

Researchers from SRILS and Tongji University discovered a hierarchical regulatory network where m⁶A modification on L1PA RNA governs LTR silencing and restrains totipotency in human embryonic stem cells.

2025.09.18 | RESEARCH

Protein & Cell | Lulu Hu's Team at SRILS Maps the Landscape of Cell Surface RNA

The team led by Core Investigator Lulu Hu proposed a unified tool for comprehensive analysis, imaging, and quantification of RNA on the surface of intact living cells.

2025.06.04 | RESEARCH

Nature | Sycamore Research Institute Professor Yanhui Xu's Team Reveals Dynamic Process of RNA Polymerase III Transcription Initiation

The Xu team reconstructed the complete dynamic process of human Pol III transcription initiation, revealing the molecular mechanism by which transcription factors and polymerase catalytic activity synergistically drive the transition from initiation to elongation.