徐彦辉教授，现任上海梧桐岛生命科学研究院科研执行院长、复旦大学附属肿瘤医院研究员。
其团队综合运用结构生物学等手段，致力于在原子水平解析生物大分子功能机制。他在人源转录起始复合物（PIC）组装调控领域取得里程碑式突破，成功体外重构含百余个蛋白的完整转录机器。此外，团队正开发基于核酸标签抗体的单细胞多组学新技术，深入探究细胞信号传递与病理关联，推动对复杂生命系统的理解及临床应用。
徐彦辉
执行院长 / 核心研究员
致力于 转录起始的分子机制，单细胞多组学技术及应用
新基石研究员
科学探索奖
长江学者
学术简介
代表性成果
2025
Structural insights into human Pol III transcription initiation in action
Qianmin Wang, Yulei Ren, Qianwei Jin, Xizi Chen, Yanhui Xu
Nature
DOI
2023
Structural visualization of transcription initiation in action
Xizi Chen; Weida Liu; Qianmin Wang; Xinxin Wang; Yulei Ren; Xuechun Qu; Wanjun Li; Yanhui Xu
Science
DOI
2022
Structures of +1 nucleosome–bound PIC-Mediator complex
Xizi Chen; Xinxin Wang; Weida Liu; Yulei Ren; Xuechun Qu; Jiabei Li; Xiaotong Yin; Yanhui Xu
Science
DOI
2021
Structures of the human Mediator and Mediator-bound preinitiation complex
Xizi Chen; Xiaotong Yin; Jiabei Li; Zihan Wu; Yilun Qi; Xinxin Wang; Weida Liu; Yanhui Xu
Science
DOI
2020
Structure of nucleosome-bound human BAF complex
Shuang He; Zihan Wu; Yuan Tian; Zishuo Yu; Jiali Yu; Xinxin Wang; Jie Li; Bijun Liu; Yanhui Xu
Science
DOI
2020
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
Hai Zheng, Yilun Qi, Shibin Hu, Xuan Cao, Congling Xu, Zhinang Yin, Xizi Chen, Yan Li, Weida Liu, Jie Li, Jiawei Wang, Gang Wei, Kaiwei Liang, Fei Xavier Chen, Yanhui Xu
Science
DOI
2015
Structural insight into substrate preference for TET-mediated oxidation
Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo, Yanhui Xu
Nature
DOI
2013
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Lulu Hu, Ze Li, Jingdong Cheng, Qinhui Rao, Wei Gong, Mengjie Liu, Yujiang Geno Shi, Jiayu Zhu, Ping Wang, Yanhui Xu
Cell
DOI
2010
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Ying Yang, Lulu Hu, Ping Wang, Haifeng Hou, Yan Lin, Yi Liu, Ze Li, Rui Gong, Xiang Feng, Lu Zhou, Wen Zhang, Yuhui Dong, Huirong Yang, Hanqing Lin, Yiqin Wang, Charlie Degui Chen, Yanhui Xu
Cell Research
DOI