Research
Epigenetic Regulation, Stem Cell Development
Our Team
Yawei Gao
Principal Investigator
Publications
2026
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Ruonan Tian; Yawei Gao; Shaorong Gao; Hongqing Liang; Xijia Chen; Weikang Meng; Jiabao Bu; Jiaxu Wang; Yuli Qian; Danya Wu; Zhengyi Li; Fei Huang; Yun-Shen Chan; Jun Ma; You Wu; Yangquan Xiang; Zhipeng Ai; Dan Zhang; Wanlu Liu; Li Shen
Science
DOI
2025
Benchmarking single-cell multi-modal data integrations
Shaliu Fu, Shuguang Wang, Duanmiao Si, Gaoyang Li, Yawei Gao, Qi Liu
Nature Methods
DOI
2025
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions
Lei Yang; Mingli Ma; Yawei Gao; Jun Liu
Current Opinion in Genetics & Development
DOI
2025
FMR1 KH0-KH1 Domains Coordinate m6A Binding and Phase Separation in Fragile X Syndrome
Xian Zhou; Chen-Jun Guo; Rui Wang; Yi-Lan Li; Tianyi Zhang; Zhuangyi Qiu; Shaorong Gao; Ji-Long Liu; Yawei Gao
Journal Article
DOI
2025
FMR1 KH0-KH1 domains coordinate m6A binding and phase separation in Fragile X syndrome
Xian Zhou; Chen-Jun Guo; Rui Wang; Yi-Lan Li; Tianyi Zhang; Zhuangyi Qiu; Shaorong Gao; Ji-Long Liu; Yawei Gao
Experimental Cell Research
DOI
2025
BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing
Moping Xu; Xiaoyang Liu; Miao Wang; Tingting Luo; Yawei Gao; Jun Liu; Jiejun Shi
Nucleic Acids Research
DOI
2024
Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development
Wenju Liu; Chuan Chen; Yawei Gao; Xinyu Cui; Yuhan Zhang; Liang Gu; Yuanlin He; Jing Li; Shaorong Gao; Rui Gao; Cizhong Jiang; Fuchou Tang
Genomics, Proteomics & Bioinformatics
DOI
2023
Resetting histone modifications during human prenatal germline development
Rui Gao; Shiyang Zeng; Dongxu Yang; Xiaocui Li; Wenqiang Liu; Yawei Gao; Dandan Bai; Linfeng Zhang; Chuan Chen; Yunzhe Kang; Beiying Wang; Wei Hong; Mingzhu Wang; Jiqing Yin; Hong Wang; Qiaolin Deng; Shaorong Gao; Yong Zhang; Jiayu Chen
Cell Discovery
DOI
2021
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.
Detailed Authors Missing in ORCID
Protein & cell
DOI
2020
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu; Xiaoyang Dou; Chuanyuan Chen; Chuan Chen; Chang Liu; Meng Michelle Xu; Siqi Zhao; Bin Shen; Yawei Gao; Dali Han; Chuan He
Science
DOI
2019
Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
Detailed Authors Missing in ORCID
Cell reports
DOI
2019
Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs
Detailed Authors Missing in ORCID
Journal of Molecular Cell Biology
DOI
2018
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos
Detailed Authors Missing in ORCID
Cell Stem Cell
DOI
2018
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Chenfei Wang; Xiaoyu Liu; Yawei Gao; Lei Yang; Chong Li; Wenqiang Liu; Chuan Chen; Xiaochen Kou; Yanhong Zhao; Jiayu Chen; Yixuan Wang; Rongrong Le; Hong Wang; Tao Duan; Yong Zhang; Shaorong Gao
Nature Cell Biology
DOI
2017
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Detailed Authors Missing in ORCID
Cell reports
DOI
2016
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Xiaoyu Liu, Chenfei Wang, Wenqiang Liu, Jingyi Li, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang, Yawei Gao, Shaorong Gao
Nature
DOI
2016
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.
Detailed Authors Missing in ORCID
Cell discovery
DOI
2015
The Combination of Tet1 with Oct4 Generates High-Quality Mouse-Induced Pluripotent Stem Cells
Jiayu Chen, Yawei Gao, Hua Huang, Kai Xu, Xia Chen, Yonghua Jiang, Hui Li, Shuai Gao, Yu Tao, Hong Wang, Yong Zhang, Hailin Wang, Tao Cai, Shaorong Gao
Stem Cells
DOI
2014
Xist Deficiency and Disorders of X-Inactivation in Rabbit Embryonic Stem Cells Can Be Rescued by Transcription-Factor-Mediated Conversion
Yonghua Jiang, Zhaohui Kou, Tong Wu, Weidong An, Ran Zhou, Hong Wang, Yawei Gao, Shaorong Gao
Stem Cells and Development
DOI
2014
2013
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
Yawei Gao, Jiayu Chen, Ke Li, Tong Wu, Bo Huang, Wenqiang Liu, Xiaochen Kou, Yu Zhang, Hua Huang, Yonghua Jiang, Chao Yao, Xiaolei Liu, Zhiwei Lu, Zijian Xu, Lan Kang, Jun Chen, Hailin Wang, Tao Cai, Shaorong Gao
Cell Stem Cell
DOI
Contact
高亚威 Lab
Sycamore Research Institute of Life Sciences
No. 88 Zhangjiang Road, Pudong New Area
Shanghai, China