高亚威

核心研究员
致力于 早期胚胎发育中的表观重编程差异,RNA 与核内多重表观组学交互机制,核移植引发的表观缺陷与分子障碍,微量组学技术与转录后调控

学术简介

高亚威研究员是发育生物学与表观遗传学专家,现任同济大学生命科学与技术学院教授、上海梧桐岛生命科学研究院核心研究员。

她的研究团队长期致力于早期胚胎发育、转分化及诱导重编程过程中的多层级表观调控机制研究。通过建立全球领先的微量测序技术,她在国际上首次探索了早期胚胎中多种组蛋白修饰的重塑规律,并开拓了 RNA 表观修饰对转录调控的新方向。

相关创新成果发表于 Nature, Science, Cell Stem Cell, Nature Cell Biology 等顶尖期刊,多次入选“中国生命科学十大进展”及 ESI 高被引论文。

代表性成果

2026
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Ruonan Tian; Yawei Gao; Shaorong Gao; Hongqing Liang; Xijia Chen; Weikang Meng; Jiabao Bu; Jiaxu Wang; Yuli Qian; Danya Wu; Zhengyi Li; Fei Huang; Yun-Shen Chan; Jun Ma; You Wu; Yangquan Xiang; Zhipeng Ai; Dan Zhang; Wanlu Liu; Li Shen
Science DOI
2025
FMR1 KH0-KH1 domains coordinate m6A binding and phase separation in Fragile X syndrome
Xian Zhou; Chen-Jun Guo; Rui Wang; Yi-Lan Li; Tianyi Zhang; Zhuangyi Qiu; Shaorong Gao; Ji-Long Liu; Yawei Gao
Experimental Cell Research DOI
2024
Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development
Wenju Liu; Chuan Chen; Yawei Gao; Xinyu Cui; Yuhan Zhang; Liang Gu; Yuanlin He; Jing Li; Shaorong Gao; Rui Gao; Cizhong Jiang; Fuchou Tang
Genomics, Proteomics & Bioinformatics DOI
2023
Resetting histone modifications during human prenatal germline development
Rui Gao; Shiyang Zeng; Dongxu Yang; Xiaocui Li; Wenqiang Liu; Yawei Gao; Dandan Bai; Linfeng Zhang; Chuan Chen; Yunzhe Kang; Beiying Wang; Wei Hong; Mingzhu Wang; Jiqing Yin; Hong Wang; Qiaolin Deng; Shaorong Gao; Yong Zhang; Jiayu Chen
Cell Discovery DOI
2021
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.
Detailed Authors Missing in ORCID
Protein & cell DOI
2020
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu; Xiaoyang Dou; Chuanyuan Chen; Chuan Chen; Chang Liu; Meng Michelle Xu; Siqi Zhao; Bin Shen; Yawei Gao; Dali Han; Chuan He
Science DOI
2019
Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
Detailed Authors Missing in ORCID
Cell reports DOI
2019
Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs
Detailed Authors Missing in ORCID
Journal of Molecular Cell Biology DOI
2018
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos
Detailed Authors Missing in ORCID
Cell Stem Cell DOI
2018
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Chenfei Wang; Xiaoyu Liu; Yawei Gao; Lei Yang; Chong Li; Wenqiang Liu; Chuan Chen; Xiaochen Kou; Yanhong Zhao; Jiayu Chen; Yixuan Wang; Rongrong Le; Hong Wang; Tao Duan; Yong Zhang; Shaorong Gao
Nature Cell Biology DOI
2017
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Detailed Authors Missing in ORCID
Cell reports DOI
2016
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Xiaoyu Liu, Chenfei Wang, Wenqiang Liu, Jingyi Li, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang, Yawei Gao, Shaorong Gao
Nature DOI
2016
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.
Detailed Authors Missing in ORCID
Cell discovery DOI
2015
The Combination of Tet1 with Oct4 Generates High-Quality Mouse-Induced Pluripotent Stem Cells
Jiayu Chen, Yawei Gao, Hua Huang, Kai Xu, Xia Chen, Yonghua Jiang, Hui Li, Shuai Gao, Yu Tao, Hong Wang, Yong Zhang, Hailin Wang, Tao Cai, Shaorong Gao
Stem Cells DOI
2014
Xist Deficiency and Disorders of X-Inactivation in Rabbit Embryonic Stem Cells Can Be Rescued by Transcription-Factor-Mediated Conversion
Yonghua Jiang, Zhaohui Kou, Tong Wu, Weidong An, Ran Zhou, Hong Wang, Yawei Gao, Shaorong Gao
Stem Cells and Development DOI
2014
Quality Control: H2A.X Links to Better iPSCs
Yawei Gao, Shaorong Gao
Cell Stem Cell DOI
2013
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
Yawei Gao, Jiayu Chen, Ke Li, Tong Wu, Bo Huang, Wenqiang Liu, Xiaochen Kou, Yu Zhang, Hua Huang, Yonghua Jiang, Chao Yao, Xiaolei Liu, Zhiwei Lu, Zijian Xu, Lan Kang, Jun Chen, Hailin Wang, Tao Cai, Shaorong Gao
Cell Stem Cell DOI