叶畅博士，现任香港理工大学应用生物及化学科技学系助理教授、校长青年学者。
他目前负责上海梧桐岛 AI 计算平台的建设与运营，致力于构建支撑新一代生命科学研究的智能算力底座。叶博士在高性能计算（HPC）架构、大规模多组学数据解析及系统生物学领域拥有逾 15 年的深度跨学科经验。基于其在核酸修饰测序技术与单细胞组学分析领域深厚的学术积淀，他正领导团队通过整合前沿人工智能算法与算力资源，为研究院的生物大分子解析与功能创新提供核心技术保障。
学术简介
代表性成果
2025
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA
Pingluan Wang; Chang Ye; Michelle Zhao; Bochen Jiang; Chuan He
Nature Chemistry
DOI
2025
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Haoxuan Li; Guanqun Wang; Chang Ye; Zhongyu Zou; Bochen Jiang; Fan Yang; Kayla He; Chengwei Ju; Lisheng Zhang; Boyang Gao; Shun Liu; Yanming Chen; Jianhua Zhang; Chuan He
Nature Plants
DOI
2024
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Qing Dai, Chang Ye, Iryna Irkliyenko, Yiding Wang, Hui-Lung Sun, Yun Gao, Yushuai Liu, Alana Beadell, José Perea, Ajay Goel, Chuan He
Nature Biotechnology
DOI
2021
Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development
Liu, K.; Deng, S.; Ye, C.; Yao, Z.; Wang, J.; Gong, H.; Liu, L.; He, X.
Nature Methods
DOI