Jun Liu, Assistant Professor at the School of Life Sciences, Peking Liu Jun, Investigator at the School of Life Sciences, Peking University; Investigator at the Peking-Tsinghua Center for Life Sciences; and Affiliated Investigator at the Sycamore Research Institute of Life Sciences, Shanghai.
Her research focuses on the novel molecular regulatory mechanisms of RNA modifications in chromatin function and their roles in biological processes such as stem cell differentiation, early embryonic development, autoimmune diseases, and tumorigenesis. Her major achievements include: revealing the presence of RNA modifications on functional chromatin-associated RNAs, expanding the understanding of the crucial mechanisms by which chromatin-associated non-coding RNAs interact with chromatin to regulate genomic transcription and centromere stability, and elucidating their key biological functions in embryonic stem cell fate determination, thereby providing new perspectives for studying the complex regulatory networks of RNA modifications in organisms; discovering the methyltransferase-independent mechanism of METTL14 in regulating histone modification H3K27me3 and its important function in stem cell differentiation; and elucidating the regulatory mechanisms of RNA methylation modifications associated with cancer proliferation, anti-tumor immunity, and amyotrophic lateral sclerosis (ALS). Her related research has been published in international academic journals such as Cell (2024), Science (2020), Nature (2019), Nature Neuroscience (2023), and Nature Cell Biology (2018) as first (co-first) and corresponding (co-corresponding) author.