Seminar | Prof. Jun Wang: Probing Key Immune Feedback Modulators for Next-Generation Immunotherapies
Seminar Info
Topic: Probing key immune feedback modulators for next-generation immunotherapies
Speaker: Prof. Jun Wang (New York University)
Host: Prof. Yanhui Xu (Fudan University)
Time: Thursday, Jan 29, 2026, 14:00
Venue: Room 219, Building R01, NO.88 Zhangjiang Road, Pudong, Shanghai
Agenda
- PART 01 Academic Presentation
- PART 02 Q&A
- PART 03 Break
- PART 04 Introduction of SRILS
- PART 05 Lab Tour
Biography
Dr. Jun Wang is an Assistant Professor of Pathology at NYU Grossman School of Medicine. He earned a B.S. in Bioengineering from Beijing Tech University, followed by a Ph.D. in Molecular Immunology from the Chinese Academy of Sciences. He completed postdoctoral training at Johns Hopkins University and Yale University.
Dr. Wang has over two decades of experience in immunotherapy, focusing on immune checkpoint biology and novel immune receptor-ligand pathways. He pioneered the characterization of PD-1/LAG-3, Siglec-15, and other key regulatory mechanisms, establishing new paradigms for therapeutic intervention.
Abstract
Immune-checkpoint blockade, led by PD-1/PD-L1-targeted therapies, has transformed cancer treatment yet benefits only a subset of patients. Although LAG-3 targeting has recently been approved, its mechanism remains incompletely understood. We decoded the flexible dimerization features of LAG-3 and PD-1, informing alternative strategies for immunotherapy.
We further revealed a central role of TCR proximity in LAG-3-mediated suppression and developed the first checkpoint-based bispecific T-cell silencer (LAG-3/TCR BiTS). We propose that PD-1 targeting lifts a disease-induced, tissue-localized negative feedback circuit. Building on this, we uncovered novel immune feedback modulators governing tissue-level immunity, guiding the next generation of immunotherapies.
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